Choline acetyltransferase activity and cognitive domain scores of Alzheimer's patients
Choline acetyltransferase activity and cognitive domain scores of Alzheimer's patients
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DOI：
10.1016/s0197-4580(00)00090-7
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发表时间：
2000-01-01
影响因子：
4.2
通讯作者：
Thal, LJ
中科院分区：
文献类型：
--
作者：
Pappas, BA;Bayley, PJ;Thal, LJ
阿尔茨海默病患者的胆碱乙酰转移酶活性和认知领域评分、马蒂斯痴呆评定量表 (MDRS) 的项目评分以及 389 名疑似阿尔茨海默病患者的简易精神状态检查 (MMSE) 均提交至正交旋转主成分分析。最佳解决方案确定了四个因素，这些因素反映了注意力/注册、语言流畅性/推理、书写运动/实践和近期记忆等认知领域。确定了在死亡前 12 个月内接受过 MDRS 和 MMSE 的患者亚组。根据犯规因素对这些患者进行评分。然后将这些认知领域得分与死后内侧额叶皮层、下顶叶皮层和海马的胆碱乙酰转移酶（ChAT）活性相关联。内侧额叶和下顶叶皮层的 ChAT 活性与书写运动/实践因子得分显着相关。内侧额叶 ChAT 也与注意力/注册得分显着相关。海马 ChAT 仅与近期记忆评分显着相关。这些结果与当前有关选择性胆碱能损伤对行为影响的动物研究一致。 (C) 2000 Elsevier Science Inc. 保留所有权利。
Choline acetyltransferase activity and cognitive domain scores of Alzheimer's patients, item scores from the Mattis Dementia Rating Scale (MDRS) and the Mini-Mental State Examination (MMSE) from 389 patients with probable Alzheimer's disease were submitted to principal component analysis with orthogonal rotation. The optimal solution identified four factors that reflected the cognitive domains of attention/registration, verbal fluency/reasoning, graphomotor/praxis and recent memory. A subgroup of patients was identified for whom both the MDRS and the MMSE had been administered within the 12 months before death. Scores were assigned to these patients for the foul factors. These cognitive-domain scores were then correlated with postmortem choline acetyltransferase (ChAT) activity in the medial frontal cortex, inferior parietal cortex, and hippocampus. ChAT activity in both the medial frontal and the inferior parietal cortex significantly correlated with scores on the graphomotor/praxis factor. Medial frontal ChAT also correlated significantly with the attention/registration scores. Hippocampal ChAT correlated significantly only with recent memory scores. These results are consistent with current animal research regarding the effect of selective cholinergic lesions on behavior. (C) 2000 Elsevier Science Inc. All rights reserved.