Effects of coping skills training and sertraline in patients with non-cardiac chest pain: a randomized controlled study.
Effects of coping skills training and sertraline in patients with non-cardiac chest pain: a randomized controlled study.
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DOI：
10.1016/j.pain.2010.08.040
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发表时间：
2011-04
期刊：
影响因子：
7.4
通讯作者：
Bradley L
中科院分区：
文献类型：
--
作者：
Keefe FJ;Shelby RA;Somers TJ;Varia I;Blazing M;Waters SJ;McKee D;Silva S;She L;Blumenthal JA;O'Connor J;Knowles V;Johnson P;Bradley L
非心源性胸痛（NCCP）是一种常见且令人痛苦的疾病。先前的研究表明，精神药物或疼痛应对技能训练（CST）可能有利于NCCP患者。据我们所知，没有临床试验研究单独和联合的影响，CST和精神药物的管理NCCP。这项随机临床试验研究了CST和抗抑郁药（舍曲林）在非心源性胸痛患者中的单独和联合作用。被诊断为NCCP的个体样本被随机分配到四种治疗之一：（1）CST加舍曲林（CST +舍曲林），（2）CST加安慰剂（CST +安慰剂），（3）单独舍曲林，或（4）单独安慰剂。在治疗前以及随机分组后10周和34周收集疼痛强度、疼痛不适、焦虑、疼痛灾难化、抑郁和身体残疾的评估。数据分析显示，CST和舍曲林单独或联合使用显着降低疼痛强度和疼痛不适。CST加舍曲林的组合可能具有最大的希望，因为当与单独的安慰剂相比时，它不仅显着减少疼痛，而且还减少疼痛灾难化和焦虑。总体而言，这些发现支持了进一步研究CST和舍曲林对非心源性胸痛影响的重要性。
Non-cardiac chest pain (NCCP) is a common and distressing condition. Prior studies suggest that psychotropic medication or pain coping skills training (CST) may benefit NCCP patients. To our knowledge, no clinical trials have examined the separate and combined effects of CST and psychotropic medication in the management of NCCP. This randomized clinical trial examined the separate and combined effects of CST and antidepressant medication (sertraline) in participants with non-cardiac chest pain. A sample of individuals diagnosed with NCCP was randomly assigned to one of four treatments: (1) CST plus sertraline (CST + sertraline), (2) CST plus placebo (CST + placebo), (3) sertraline alone, or (4) placebo alone. Assessments of pain intensity, pain unpleasantness, anxiety, pain catastrophizing, depression, and physical disability were collected prior to treatment, and at 10- and 34-weeks following randomization. Data analyses revealed that CST and sertraline either alone or in combination significantly reduced pain intensity and pain unpleasantness. The combination of CST plus sertraline may have the greatest promise in that, when compared to placebo alone, it not only significantly reduced pain but also pain catastrophizing and anxiety. Overall, these findings support the importance of further research on the effects of CST and sertraline for non-cardiac chest pain.
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影响因子：
11.1
作者：
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