Adjudin attenuates lipopolysaccharide (LPS)- and ischemia-induced microglial activation.
Adjudin attenuates lipopolysaccharide (LPS)- and ischemia-induced microglial activation.
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Adjudin 减弱脂多糖 (LPS) 和缺血诱导的小胶质细胞活化
DOI：
10.1016/j.jneuroim.2012.09.012
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发表时间：
2013-01-15
影响因子：
3.3
通讯作者：
Xia, Weiliang
中科院分区：
文献类型：
--
作者：
Shao, Jiaxiang;Liu, Tengyuan;Xie, Qian Reuben;Zhang, Tingting;Yu, Hemei;Wang, Boshi;Ying, Weihai;Mruk, Dolores D.;Silvestrini, Bruno;Cheng, C. Yan;Xia, Weiliang
Neuroinflammation caused by microglial activation plays a key role in ischemia, neurodegeneration and many other CNS diseases. In this study, we found that Adjudin, a potential non-hormonal male contraceptive, exhibits additional function to reduce the production of proinflammatory mediators. Adjudin significantly inhibited LPS-induced IL-6 release and IL-6, IL-1β, TNF-α expression in BV2 microglial cells. Furthermore, Adjudin exhibited anti-inflammatory properties by suppression of NF-κB p65 nuclear translocation and DNA binding activity as well as ERK MAPK phosphorylation. To determine the in vivo effect of Adjudin, we used a permanent middle cerebral artery occlusion (pMCAO) mouse model and found that Adjudin could reduce ischemia-induced CD11b expression, a marker of microglial activation. Furthermore, Adjudin treatment attenuated brain edema and neurological deficits after ischemia but did not reduce infarct volume. Thus, our data suggest that Adjudin may be useful for mitigating neuroinflammation.
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影响因子：
82.9
作者：
Manley, GT;Fujimura, M;Verkman, AS
通讯作者：
Verkman, AS
影响因子：
6.2
作者：
Qin, LY;Li, GR;Block, ML
通讯作者：
Block, ML
影响因子：
6.3
作者：
Chen, JL;Zhang, CL;Chopp, M
通讯作者：
Chopp, M
影响因子：
3.6
作者：
Cheng, CY;Silvestrini, B;Mruk, D
通讯作者：
Mruk, D
DOI：
10.1530/rep-10-0464
发表时间：
2011-05
期刊：
Reproduction (Cambridge, England)
影响因子：
--
作者：
Mok KW;Mruk DD;Lie PP;Lui WY;Cheng CY
通讯作者：
Cheng CY