Antimicrobial Peptide Expression at the Ocular Surface and Their Therapeutic Use in the Treatment of Microbial Keratitis.
Antimicrobial Peptide Expression at the Ocular Surface and Their Therapeutic Use in the Treatment of Microbial Keratitis.
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DOI：
10.3389/fmicb.2022.857735
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发表时间：
2022
影响因子：
5.2
通讯作者：
Leonard, Brian C.
中科院分区：
文献类型：
--
作者：
Shannon, Allison H.;Adelman, Sara A.;Hisey, Erin A.;Potnis, Sanskruti S.;Rozo, Vanessa;Yung, Madeline W.;Li, Jennifer Y.;Murphy, Christopher J.;Thomasy, Sara M.;Leonard, Brian C.
微生物性角膜炎是世界范围内眼痛和视力损害的常见原因。眼表面具有相对少细胞的微生物群落，主要存在于结膜中，而角膜被认为是相对无菌的。然而，在患有微生物角膜炎的患者中，角膜可被多种病原体感染，包括金黄色葡萄球菌、铜绿假单胞菌和镰刀菌。局部抗菌药物治疗作为微生物角膜炎的标准治疗，然而，由于病原体对当前抗菌药物的耐药性高，必须开发替代治疗策略。多项研究已经表征了抗微生物肽（AMP）在眼表面上的表达和活性，所述抗微生物肽是具有关键抗微生物和伤口愈合特性的内源性肽。最近的研究和临床试验为AMP作为治疗剂的用途提供了希望。本文综述了在眼表表达的AMP的库，这些AMP的表达可以如何调制，以及利用AMP作为潜在的治疗微生物性角膜炎患者的潜力。
Microbial keratitis is a common cause of ocular pain and visual impairment worldwide. The ocular surface has a relatively paucicellular microbial community, mostly found in the conjunctiva, while the cornea would be considered relatively sterile. However, in patients with microbial keratitis, the cornea can be infected with multiple pathogens including Staphylococcus aureus, Pseudomonas aeruginosa, and Fusarium sp. Treatment with topical antimicrobials serves as the standard of care for microbial keratitis, however, due to high rates of pathogen resistance to current antimicrobial medications, alternative therapeutic strategies must be developed. Multiple studies have characterized the expression and activity of antimicrobial peptides (AMPs), endogenous peptides with key antimicrobial and wound healing properties, on the ocular surface. Recent studies and clinical trials provide promise for the use of AMPs as therapeutic agents. This article reviews the repertoire of AMPs expressed at the ocular surface, how expression of these AMPs can be modulated, and the potential for harnessing the AMPs as potential therapeutics for patients with microbial keratitis.
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影响因子：
4.4
作者：
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通讯作者：
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影响因子：
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DOI：
10.1002/jss.400020504
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期刊：
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影响因子：
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作者：
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