Effect of smoking during pregnancy on the risk of cancer in children.
Effect of smoking during pregnancy on the risk of cancer in children.
复制标题
怀孕期间吸烟对儿童患癌症风险的影响。
DOI：
10.1093/jnci/47.1.59
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发表时间：
1971
期刊：
影响因子：
--
通讯作者：
Carol Buck
中科院分区：
文献类型：
--
作者：
C. Neutel;Carol Buck
从安大略围产期死亡率研究和英国围产期死亡率调查中，89,302名存活至少7天的婴儿作为基础人群（或关于怀孕期间吸烟与后代癌症之间关系的前瞻性研究）。母亲在怀孕期间的吸烟习惯在孩子出生之前或之后被记录下来。在这两个基准人口中，从出生到最小7岁和最大10岁期间，共有65人死于癌症，32人幸存。对于所有部位的癌症，吸烟者的子女的相对风险为1.3，95%置信限为0.8-2.2。缺乏剂量-反应关系的证据。尽管这些结果表明子宫暴露于烟草烟雾对胎儿具有广泛致癌作用的可能性极小，但不能排除仅限于一种组织或在一个狭窄的年龄范围内表现出的反应。
From the Ontario Perinatal Mortality Study and the British Perinatal Mortality Survey, 89,302 babies surviving at least 7 days served as a base population (or a prospective study of the relationship between smoking in pregnancy and cancer in the offspring. The smoking habits of the mother during pregnancy were recorded before or just after the birth of the child. In the two base populations combined, there were 65 cancer deaths and 32 cancer survivors in the period from birth to a minimum of 7 and a maximum of 10 years of age. For cancer of all sites, the children of smokers had a relative risk of 1.3 with 95% confidence limits of 0.8–2.2. Evidence of a dose-response relationship was lacking. Although these results make it most unlikely thatin uteroexposure to tobacco smoke has a broadly carcinogenic effect on the fetus, a response confined to one tissue or expressed over a narrow age range cannot be ruled out.