Differential effects of COMT on gait and executive control in aging
Differential effects of COMT on gait and executive control in aging
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DOI：
10.1016/j.neurobiolaging.2008.05.011
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发表时间：
2010-03-01
影响因子：
4.2
通讯作者：
Verghese, J.
中科院分区：
文献类型：
--
作者：
Holtzer, R.;Ozelius, L.;Verghese, J.
步行速度与前额叶皮质所支持的注意力和执行控制过程有关。由于儿茶酚 - O - 甲基转移酶（COMT）的多态性会影响这些认知过程，我们假设相同的多态性可能会影响步态速度。我们研究了COMT基因的Val(158)Met多态性与步态速度以及注意力和执行功能之间的关联。参与者为278名无痴呆的老年人。结果显示，甲硫氨酸（Met）/缬氨酸（Val）与更快的步态速度相关。这种关联可以通过Val等位基因在调节纹状体中多巴胺的紧张性释放方面的假定作用来解释。相反，Met/Met与更好的注意力和执行功能相关。按性别分层显示，COMT基因型与步态之间的关联仅在男性中显著。相反，COMT基因型与注意力和执行功能之间的关联仅在女性中显著。这些发现表明，在将Val(158)Met多态性与步态和认知功能相关联方面存在差异效应，同时支持了先前描述的COMT表型表达的性别二态性。（C）2008爱思唯尔公司。保留所有权利。
Walking speed is associated with attention and executive control processes subserved by the prefrontal cortex. Because polymorphisms in catechol-O-methyltransferase (COMT) influence these cognitive processes we hypothesized that the same polymorphisms may influence gait velocity. We examined the associations between the Val(158)Met polymorphism in COMT and gait velocity as well as attention and executive function. Participants were 278 non-demented older adults. The results revealed that methionine (Met)/valine (Val) was associated with faster gait velocity. This association can be explained by the putative role of the Val allele in regulating tonic dopamine release in the striatum. In contrast, Met/Met was associated with better attention and executive function. Stratification by gender revealed that the association between COMT genotype and gait was significant only in men. Conversely, the association between COMT genotype and attention and executive function was significant only in women. These findings suggest a differential effect in relating the Val(158)Met polymorphism to gait and to cognitive function while supporting the previously described sexual dimorphism in the phenotypic expressions of COMT. (C) 2008 Elsevier Inc. All rights reserved.