24 year outcomes of hepatitis B vaccination in Hangzhou, China
24 year outcomes of hepatitis B vaccination in Hangzhou, China
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DOI：
10.1080/21645515.2015.1008873
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发表时间：
2015-02
影响因子：
4.8
通讯作者：
Jian Du;Yuyang Xu;Jun Wang;Shijun Liu;Yan Liu;Xiaoping Zhang;Erping Xu
中科院分区：
文献类型：
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作者：
Jian Du;Yuyang Xu;Jun Wang;Shijun Liu;Yan Liu;Xiaoping Zhang;Erping Xu
评价中国杭州市普及婴儿B型肝炎疫苗接种计划对B型肝炎病毒感染的影响。方法：收集杭州市1990 - 2003年乙肝B发病率和乙肝B疫苗接种率的历史纸质资料，并分别来源于2004 - 2013年中国疾病预防控制信息系统和浙江省免疫规划信息系统。2006年对杭州市0-59岁人群进行了血清学调查.参与者通过分层、多阶段随机抽样进行选择。用ELISA法检测血清HBsAg、抗-HBs、抗-HBc、HBeAg和抗-HBe。24年来，杭州市B型肝炎发病率和死亡率明显下降（χ2 = 3.2 × 104; χ2 = 172.443;趋势P均< 0.001）。城市和农村发病率均呈下降趋势（χ 2城市= 1.904 × 104; χ 2农村= 1.633 × 104 ;趋势均P < 0.001），B型肝炎患者主要集中在20-40岁年龄段，职业以工人和农民为主，不同年份发病率不同（χ2 = 1.619 × 103，P < 0.001）。B发病率与乙肝疫苗接种率呈显著相关（r = 0.946，χ2 = 11.813，P趋势= 0.001）。共5605名0-59岁的参与者被纳入本次血清学调查。HBsAg、抗-HBs、抗-HBc、HBeAg和抗-HBe的检出率分别为6.19%、45.83%、57.25%、0.62%和4.37%。杭州市成功地将B型肝炎纳入常规免疫规划，对降低B型肝炎发病率产生了显著影响。
To evaluate the impact of the universal infant HepB vaccination program on hepatitis B virus infection in Hangzhou, China. Hepatitis B incidences and HepB vaccination rates of Hangzhou from 1990 to 2003 were acquired from the historical paper-documents, while which were derived from China Information System for Diseases Control and Prevention and Zhejiang Information System for Immunization Program respectively from 2004 to 2013. A serology survey among person aged 0–59 y was conducted in Hangzhou in 2006. Participants were selected by stratified, multi-stage random sampling. Serum specimens were tested for HBsAg, anti-HBs , anti-HBc , HBeAg and anti-HBe by ELISA. For the past 24 years, hepatitis B incidence and mortality of Hangzhou declined dramatically (χ2 = 3.2 × 104; χ2 = 172.443; both P for trend < 0.001). Both urban and rural incidence descended (χ2urban = 1.904 × 104; χ2rural = 1.633 × 104 ; both P for trend < 0.001).Hepatitis B patients mainly concentrated in 20–40 y old; workers and farmers were the main infection occupations, which was varies in different years (χ2 = 1.619 × 103, P < 0.001). Significant association was found between incidence of hepatitis B and HepB vaccination rate (r = 0 .946, χ2 = 11.813, Pfor trend = 0.001). A total of 5605 participants aged 0–59 y included in this serological survey. The prevalence of HBsAg, anti-HBs, anti-HBc, HBeAg and anti-HBe were 6.19%, 45.83%, 57.25%, 0.62%, and 4.37%, respectively. Hangzhou has successfully integrated the HepB into routine immunization programs and this has had a significant impact on decreasing the incidence of hepatitis B infection.