Uptake and supply of purine compounds by the liver.
Uptake and supply of purine compounds by the liver.
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肝脏对嘌呤化合物的摄取和供应。
DOI：
10.1152/ajplegacy.1975.229.4.967
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发表时间：
1975
期刊：
影响因子：
--
通讯作者：
R. Berlin
中科院分区：
文献类型：
--
作者：
J. B. Pritchard;N. O'Connor;J. Oliver;R. Berlin
我们分析了轻度麻醉的兔子和大鼠体内进出肝脏的嘌呤化合物，以及从灌注奥昔嘌呤的肝脏中输出可利用的嘌呤。体内结果表明，大约 80% 的次黄嘌呤、黄嘌呤和尿酸盐在血液通过肝脏的单次通道中被去除。相反，肝静脉血的腺苷浓度比门脉或动脉血水平增加 10 倍。当分离肝脏并用次黄嘌呤灌注时，无论是通过微生物测定定量测量还是通过对从已用[14C]次黄嘌呤预先标记的肝脏释放的放射性嘌呤进行分析来定量测量，都会有显着的腺苷释放。这些结果为肝脏清除羟基嘌呤和释放可利用的腺嘌呤衍生物提供了直接证据。
We have analyzed for purine compounds entering and leaving the liver in lightly anesthetized rabbits and rats and for the export of utilizable purine from liver perfused with oxypurine. The in vivo results indicate that roughly 80% of hypoxanthine, xanthine, and urate is removed in a single passage of blood through liver. Conversely, the adenosine concentration of hepatic venous blood is increased 10-fold over portal or arterial levels. When the liver is isolated and perfused with hypoxanthine there is significant release of adenosine, whether measured quantitatively by microbiological assay or qualitatively by analysis of the radioactive purines released from liver that has been prelabeled with [14C]hypoxanthine. These results provide direct evidence for the clearance of hydroxylated purines and the release of utilizable adenine derivatives by liver.