Oxidative Stress and Inflammation in Hepatic Diseases: Therapeutic Possibilities of N-Acetylcysteine.
Oxidative Stress and Inflammation in Hepatic Diseases: Therapeutic Possibilities of N-Acetylcysteine.
复制标题
DOI：
10.3390/ijms161226225
复制
发表时间：
2015-12-18
影响因子：
5.6
通讯作者：
Goulart MO
中科院分区：
文献类型：
--
作者：
de Andrade KQ;Moura FA;dos Santos JM;de Araújo OR;de Farias Santos JC;Goulart MO
肝病在世界上高度流行。氧化应激(OS)和炎症是肝脏疾病中最重要的致病事件，无论其病因和自然病程如何。N-乙酰-L-半胱氨酸(活性形式)(NAC)正在研究中，用于治疗以OS升高或谷胱甘肽(GSH)水平降低为特征的疾病。NAC主要作用于GSH合成过程中半胱氨酸的供应。本综述的目的是评价NAC在减轻肝脏损伤的炎症标志物和OS方面的抗氧化和抗炎作用的实验和临床研究。与补充NAC有关的结果在任何给药形式和研究类型的85.5%(n=59)被评估的病例(n=69,100%)中是满意的。在这一百分比中，体内研究中使用的NAC剂量从0.204到2g/kg/天不等。在动物模型中，需要标准的保护和治疗实验设计以及给药途径的选择，并对血清或其他生物基质中的OS和炎症标志物进行更广泛的评估。迫切需要临床研究，以便有一个清晰的视野，以便专业人员能够确定NAC处方的有效性和安全性。
Liver disease is highly prevalent in the world. Oxidative stress (OS) and inflammation are the most important pathogenetic events in liver diseases, regardless the different etiology and natural course. N-acetyl-l-cysteine (the active form) (NAC) is being studied in diseases characterized by increased OS or decreased glutathione (GSH) level. NAC acts mainly on the supply of cysteine for GSH synthesis. The objective of this review is to examine experimental and clinical studies that evaluate the antioxidant and anti-inflammatory roles of NAC in attenuating markers of inflammation and OS in hepatic damage. The results related to the supplementation of NAC in any form of administration and type of study are satisfactory in 85.5% (n = 59) of the cases evaluated (n = 69, 100%). Within this percentage, the dosage of NAC utilized in studies in vivo varied from 0.204 up to 2 g/kg/day. A standard experimental design of protection and treatment as well as the choice of the route of administration, with a broader evaluation of OS and inflammation markers in the serum or other biological matrixes, in animal models, are necessary. Clinical studies are urgently required, to have a clear view, so that, the professionals can be sure about the effectiveness and safety of NAC prescription.