Impacts of different methods of conception on the perinatal outcome of intrahepatic cholestasis of pregnancy in twin pregnancies.
Impacts of different methods of conception on the perinatal outcome of intrahepatic cholestasis of pregnancy in twin pregnancies.
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DOI：
10.1038/s41598-018-22387-6
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发表时间：
2018-03-05
影响因子：
4.6
通讯作者：
Wang LQ
中科院分区：
文献类型：
--
作者：
Feng C;Li WJ;He RH;Sun XW;Wang G;Wang LQ
双胎妊娠肝内胆汁淤积症的患病率高于单胎妊娠。目前尚不清楚体外受精-胚胎移植(IVF-ET)是否会影响双胎妊娠合并妊娠肝内胆汁淤积症的胎儿结局。本研究旨在探讨体外受精-胚胎移植(IVF-ET)对双胎妊娠妊娠肝内胆汁淤积症围产儿结局的影响。回顾分析142例双胎妊娠合并妊娠肝内胆汁淤积症的临床资料，其中IVF-ET妊娠51例(IVF组)，自然妊娠91例(SC组)。分析几项生化指标及围产儿结局。与SC组相比，体外受精组早发性肝内胆汁淤积症的发生率更高(P = 0.015)，临床症状也更常见(P = 0.020)，包括皮肤瘙痒、皮肤抓挠和黄疸。此外，与SC组相比，体外受精组新生儿窒息(9.80%vs SC，P = 0.023)和早产率(IVF vs SC，96.08%vs 83.52%，P = 0.027)更高。体外受精双胎妊娠组早发性肝内胆汁淤积症的风险较高，临床症状和围产儿结局较差。
Twin pregnancies have a higher prevalence of intrahepatic cholestasis of pregnancy (ICP) than single pregnancies. It is unknown whether in vitro fertilization-embryo transfer (IVF-ET) influences the fetal outcomes in twin pregnancies complicated by ICP. This study aimed to explore the impact of IVF-ET on the perinatal outcomes of ICP in twin pregnancy. Clinical data from 142 twin pregnant women complicated with ICP were retrospectively analyzed, including 51 patients who conceived through IVF-ET (IVF group) and 91 patients with spontaneous conception (SC group). Several biochemical indicators and perinatal outcomes were analyzed. Compared to the SC group, the IVF group had a higher incidence of early-onset ICP (P = 0.015) and more frequent clinical symptoms (P = 0.020), including skin pruritus, skin scratch, and jaundice. Furthermore, the IVF group had higher rates of neonatal asphyxia (IVF vs. SC, 9.80% vs. 1.10%, P = 0.023) and premature delivery (IVF vs. SC, 96.08% vs. 83.52%, P = 0.027) compared to the SC group. The IVF-conceived twin pregnancy group had a higher risk of early-onset ICP and suffered from clinical symptoms and poor perinatal outcomes.
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影响因子：
3.8
作者：
Geenes, V. L.;Lim, Y. -H.;Williamson, C.
通讯作者：
Williamson, C.
影响因子：
4.3
作者：
Kondrackiene, Jurate;Beuers, Ulrich;Kupcinskas, Limas
通讯作者：
Kupcinskas, Limas
DOI：
10.3760/cma.j.issn.0254-6450.2016.02.007
发表时间：
2016-02-01
影响因子：
--
作者：
Ge, X;Xu, Y Q;Tao, F B
通讯作者：
Tao, F B
DOI：
10.1002/hep.28265
发表时间：
2016-04
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
Abu-Hayyeh S;Ovadia C;Lieu T;Jensen DD;Chambers J;Dixon PH;Lövgren-Sandblom A;Bolier R;Tolenaars D;Kremer AE;Syngelaki A;Noori M;Williams D;Marin JJ;Monte MJ;Nicolaides KH;Beuers U;Oude-Elferink R;Seed PT;Chappell L;Marschall HU;Bunnett NW;Williamson C
通讯作者：
Williamson C
影响因子：
3.7
作者：
Estiu, Maria C.;Frailuna, Maria A.;Macias, Rocio I. R.
通讯作者：
Macias, Rocio I. R.