Combination of hesperetin and platinum enhances anticancer effect on lung adenocarcinoma
Combination of hesperetin and platinum enhances anticancer effect on lung adenocarcinoma
复制标题
橙皮素与铂联合增强对肺腺癌的抗癌作用
DOI：
10.1016/j.biopha.2019.108779
复制
发表时间：
2019
影响因子：
7.5
通讯作者：
Du Jiajun
中科院分区：
文献类型：
--
作者：
Wang Yadong;Liu Shaorui;Dong Wei;Qu Xiao;Huang Cuicui;Yan Tao;Du Jiajun
肺癌仍然是肿瘤死亡的主要原因。迫切需要发现新的分子靶点并开发新的治疗方法。UDP-葡萄糖醛酸转移酶（UGT）家族之一UGT 1A 3在肺腺癌（LUAD）中高表达，并与预后不良相关。其抑制剂橙皮素可能在抗肿瘤治疗中发挥重要作用。本研究旨在探讨UGT 1A 3在肺腺癌发生发展中的作用及其抑制剂橙皮素在LUAD治疗中的价值。橙皮素抑制肺腺癌细胞增殖和迁移。橙皮素与铂的联合治疗更显著地抑制肿瘤进展，尤其是与单药治疗相比。UGT 1A 3是LUAD的重要预后因素，橙皮素可通过抑制UGT 1A 3和增加活性氧（ROS）水平来协同铂类药物。
Lung cancer remains the leading cause of oncological death. There is an urgent need to discover new molecular targets and to develop new treatments. One of the UDP-glucuronosyltransferases (UGTs) family, UGT1A3, is highly expressed in lung adenocarcinoma (LUAD), and is associated with poor prognosis. Its inhibitor, hesperetin, may play an important role in anticancer therapy. The purpose of this study was to investigate the role of UGT1A3 in the progression of lung adenocarcinoma and to explore the value of its inhibitor hesperetin in the treatment of LUAD. Hesperetin suppressed lung adenocarcinoma cell proliferation and migration. The combination treatment of hesperetin with platinum suppressed tumor progression more significantly, especially compared with single drug treatment. UGT1A3 is an important prognostic factor for LUAD, and hesperetin can synergize platinum drugs by inhibiting UGT1A3 and increasing levels of reactive oxygen species (ROS).