Arabidopsis SOMATIC EMBRYOGENESIS RECEPTOR KINASE proteins serve brassinosteroid-dependent and -independent signaling pathways
Arabidopsis SOMATIC EMBRYOGENESIS RECEPTOR KINASE proteins serve brassinosteroid-dependent and -independent signaling pathways
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DOI：
10.1104/pp.108.123216
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发表时间：
2008-09-01
期刊：
影响因子：
7.4
通讯作者：
de Vries, Sacco C.
中科院分区：
文献类型：
--
作者：
Albrecht, Catherine;Russinova, Eugenia;de Vries, Sacco C.
拟南芥（Arabidopsis thaliana）体细胞胚胎发生受体激酶（SERK）基因属于五种植物受体激酶的小家族，其参与至少五种不同的信号传导途径。该家族的一个成员，油菜素甾醇不敏感1（BRI 1）-相关激酶1（BAK 1），也称为SERK 3，是油菜素甾醇（BR）-感知受体BRI 1的辅助受体，BRI 1的功能是BR依赖性的，并且与SERK 1部分冗余。BAK 1（SERK 3）单独控制植物先天免疫，也是鞭毛蛋白受体FLS 2的辅助受体，并且与SERK 4一起可以介导细胞死亡控制，所有三种都以BR-独立的方式。SERK 1和SERK 2是雄性小孢子发生所必需的，同样独立于BR。SERK 5在测试条件下似乎没有任何功能。在这里，我们表明，不同的SERK成员只是冗余的配对，而更高阶的突变体组合只显示加性表型。令人惊讶的是，在一个通路中冗余的SERK成员在另一个通路中并不冗余。我们还表明，这种功能对的演变发生在蛋白质功能的变化，而不是空间表达的差异。我们建议，在植物中，密切相关的受体激酶有一个最小的同源或异源二聚体的配置，以实现特异性。
The Arabidopsis (Arabidopsis thaliana) SOMATIC EMBRYOGENESIS RECEPTOR KINASE (SERK) genes belong to a small family of five plant receptor kinases that are involved in at least five different signaling pathways. One member of this family, BRASSINOSTEROID INSENSITIVE1 (BRI1)-ASSOCIATED KINASE1 (BAK1), also known as SERK3, is the coreceptor of the brassinolide (BR)-perceiving receptor BRI1, a function that is BR dependent and partially redundant with SERK1. BAK1 (SERK3) alone controls plant innate immunity, is also the coreceptor of the flagellin receptor FLS2, and, together with SERK4, can mediate cell death control, all three in a BR-independent fashion. SERK1 and SERK2 are essential for male microsporogenesis, again independent from BR. SERK5 does not appear to have any function under the conditions tested. Here, we show that the different SERK members are only redundant in pairs, whereas higher order mutant combinations only show additive phenotypes. Surprisingly, SERK members that are redundant within one are not redundant in another pathway. We also show that this evolution of functional pairs occurred by a change in protein function and not by differences in spatial expression. We propose that, in plants, closely related receptor kinases have a minimal homo-or heterodimeric configuration to achieve specificity.