A balance between antagonizing PAR proteins specifies the pattern of asymmetric and symmetric divisions in C.?elegans embryogenesis
A balance between antagonizing PAR proteins specifies the pattern of asymmetric and symmetric divisions in C.?elegans embryogenesis
复制标题
拮抗 PAR 蛋白之间的平衡指定了线虫胚胎发生中不对称和对称分裂的模式
DOI：
10.1016/j.celrep.2021.109326
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发表时间：
2021
期刊：
影响因子：
8.8
通讯作者：
Motegi Fumio
中科院分区：
文献类型：
--
作者：
Lim Yen Wei;Wen Fu-Lai;Shankar Prabhat;Shibata Tatsuo;Motegi Fumio
发育过程中细胞分化和增殖之间的协调需要细胞分裂的不对称和对称模式之间的平衡。然而，这两种分裂模式之间的选择背后的细胞内在线索仍然难以捉摸。在这里，我们显示的证据表明，在秀丽隐杆线虫的分裂模式不变的血统指定的拮抗复合物之间的平衡分配缺陷（PAR）蛋白。通过解偶联的PAR蛋白质的不平等遗传的命运决定因素在细胞分裂过程中，我们表明，PAR-2和PAR-6之间的平衡的变化可以足以重新编程的分裂模式从对称到不对称，反之亦然，在两个子细胞。所采用的分裂模式独立于胞质命运决定因素的不对称性、细胞大小的不对称性和姐妹细胞之间的细胞周期不对称性而发生。我们建议，PAR蛋白之间的平衡代表了一个内在的自组织线索的规格的两个分裂模式在发展过程中。
Coordination between cell differentiation and proliferation during development requires the balance between asymmetric and symmetric modes of cell division. However, the cellular intrinsic cue underlying the choice between these two division modes remains elusive. Here, we show evidence inCaenorhabditis elegansthat the invariable lineage of the division modes is specified by the balance between antagonizing complexes of partitioning-defective (PAR) proteins. By uncoupling unequal inheritance of PAR proteins from that of fate determinants during cell division, we demonstrate that changes in the balance between PAR-2 and PAR-6 can be sufficient to re-program the division modes from symmetric to asymmetric and vice versa in two daughter cells. The division mode adopted occurs independently of asymmetry in cytoplasmic fate determinants, cell-size asymmetry, and cell-cycle asynchrony between sister cells. We propose that the balance between PAR proteins represents an intrinsic self-organizing cue for the specification of the two division modes during development.