Respiratory-related evoked potentials in children with life-threatening asthma
Respiratory-related evoked potentials in children with life-threatening asthma
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DOI：
10.1164/ajrccm.161.6.9903077
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发表时间：
2000-06-01
影响因子：
24.7
通讯作者：
Kifle, Y
中科院分区：
文献类型：
--
作者：
Davenport, PW;Cruz, M;Kifle, Y
呼吸相关诱发电位（RREP）是通过吸气闭塞引起的，并通过体感皮层记录。第一个正峰值 (P-1) 幅度与吸气负荷的大小相关。由于患有危及生命的哮喘 (LTA) 儿童对吸气负荷的感知敏感性降低，我们假设患有 LTA 的患者亚群感知机械负荷的能力受损，并且这些患者的 RREP 异常。 RREP 是从 C-Z-C-3 和 C-Z-C-4 记录的，分为三组：LTA 哮喘儿童、控制哮喘儿童和非哮喘儿童。记录了两项吸气中断闭塞试验和一项对照试验。从平均闭塞试验中减去平均对照试验后，对所有诱发电位进行分析。在所有 14 名非哮喘儿童和 15 名对照哮喘儿童中的 14 名中均观察到 RREP P-1 峰值。 11 名 LTA 患者中有 6 名没有 RREP。当存在时，P-1 峰值潜伏期或振幅没有组间显着差异。这些结果表明，吸气闭塞引起的 RREP 在非哮喘和哮喘儿童的双侧都存在。有一个 LTA 儿童亚群，其中吸气闭塞无法引发 RREP 的 pi 峰值，这表明吸气负荷信息的神经处理发生了改变。
Respiratory-related evoked potentials (RREPs) have been elicited by inspiratory occlusion and recorded over the somatosensory cortex. The first positive peak (P-1) amplitude has been correlated with the magnitude of inspiratory loads. Since children with life-threatening asthma (LTA) have a decreased perceptual sensitivity of inspiratory loads, we hypothesized that a subpopulation of patients with LTA have an impaired ability to sense mechanical loads, and that these patients would have an abnormal RREP. The RREP was recorded from C-Z-C-3 and C-Z-C-4 in three groups: LTA asthmatic, control asthmatic, and nonasthmatic children. Two inspiratory-interruption occlusions trials and a control trial were recorded. All the evoked potentials were analyzed after the averaged control trial was subtracted from the averaged occlusion trials. The RREP P-1 peak was observed in all 14 nonasthmatic children and in 14 of 15 control asthmatic children. The RREP was absent in 6 of 11 patients with LTA. When present, there were no between-group significant differences in P-1 peak latency or amplitude. These results demonstrate that the RREP elicited by inspiratory occlusion is present bilaterally in nonasthmatic and asthmatic children. There is a subpopulation of LTA children in which inspiratory occlusion fails to elicit the pi peak of the RREP, suggesting an altered neural processing of inspiratory load information.