Mitosis in eukaryotic cells: an overview of chromosome distribution.
Mitosis in eukaryotic cells: an overview of chromosome distribution.
复制标题
真核细胞有丝分裂：染色体分布概述。
DOI：
10.1007/978-1-4613-2127-9_13
复制
发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Nicklas,RB
中科院分区：
文献类型：
--
作者：
Nicklas,RB
有丝分裂的结果通常是2个子细胞具有相同数量和种类的染色体（整倍性），而不是不相等的数量（非整倍性）。我们对潜在的机制了解得越多，这一点似乎就越值得注意：染色体的精确分布严重依赖于结构紊乱和不稳定性，而结构紊乱和不稳定性通常与不精确性有关，即与非整倍性有关。我的目的是回顾我们所知道的真核生物中染色体的分布情况，并将紊乱和不稳定与正常结果和非整倍体的起源联系起来。讨论仅限于具有局部动粒的生物体中的正统有丝分裂和减数分裂（关于非正统机制，参见，例如，参考文献19;关于有丝分裂的更广泛综述，参见参考文献16和24）。
The usual outcome of mitosis is 2 daughter cells with equal numbers and kinds of chromosomes (euploidy) rather than unequal numbers (aneuploidy). The more we learn about the underlying mechanisms the more remarkable this seems: the precise distribution of chromosomes depends critically upon structural disorder and instability, which would more commonly be associated with imprecision, that is, with aneuploidy. My aim is to review what is known about chromosome distribution in eukaryotes and to relate disorder and instability both to the normal outcome and to the origin of aneuploidy. The discussion is limited to orthodox mitosis and meiosis in organisms with localized kinetochores (on unorthodox mechanisms, see, eg-., Ref. 19; for broader reviews of mitosis, see Ref. 16 and 24).