Recent insights into the effects of metabolism on breast cancer cell dormancy.
Recent insights into the effects of metabolism on breast cancer cell dormancy.
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DOI：
10.1038/s41416-022-01869-5
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发表时间：
2022-11
影响因子：
8.8
通讯作者：
Berry CC
中科院分区：
文献类型：
--
作者：
Bartlome S;Berry CC
乳腺癌（BC）仍然是最常见的癌症，也是全球女性癌症死亡的主要原因。大约 30% 的早期 BC 患者会出现转移或复发。 BC 休眠现象是指转移的癌细胞在其播散位置保持静止状态，并且由于未知原因可能再次活跃增殖，这进一步增加了 BC 的临床负担，因为在第二阶段的治疗通常被证明是徒劳的。一个新兴的研究方向集中在休眠 BC 细胞 (BCC) 的代谢特性以及导致 BCC 进入/退出静止状态的潜在代谢变化。在这里，我们探讨了几项研究，这些研究揭示了休眠状态下碳代谢的变化，而相互矛盾的研究则揭示了向糖酵解和/或氧化磷酸化的转变。本综述强调，休眠 BCC 的代谢状态/变化似乎取决于不同的 BC 亚型和受体状态；然而，需要做更多的工作来充分了解这些差异。以本综述概述的研究为基础，可以为 BC 患者提供新的个性化治疗可能性。
Breast cancer (BC) remains the most common cancer, as well as the leading cause of cancer mortality in women worldwide. Approximately 30% of patients with early-stage BC experience metastasis or a recurrent form of the disease. The phenomenon of BC dormancy, where metastasised cancer cells remain in a quiescent phase at their disseminated location and for unknown reasons can become actively proliferative again, further adds to BC’s clinical burden with treatment at this secondary stage typically proving futile. An emerging avenue of research focuses on the metabolic properties of dormant BC cells (BCCs) and potential metabolic changes causing BCCs to enter/exit their quiescent state. Here we explore several studies that have uncovered changes in carbon metabolism underlying a dormant state, with conflicting studies uncovering shifts towards both glycolysis and/or oxidative phosphorylation. This review highlights that the metabolic states/shifts of dormant BCCs seem to be dependent on different BC subtypes and receptor status; however, more work needs to be done to fully map these differences. Building on the research that this review outlines could provide new personalised therapeutic possibilities for BC patients.
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影响因子：
11.2
作者：
Barkan D;Kleinman H;Simmons JL;Asmussen H;Kamaraju AK;Hoenorhoff MJ;Liu ZY;Costes SV;Cho EH;Lockett S;Khanna C;Chambers AF;Green JE
通讯作者：
Green JE
影响因子：
3.9
作者：
Figueroa-Magalhaes, Maria Cristina;Jelovac, Danijela;Connolly, Roisin M.;Wolff, Antonio C.
通讯作者：
Wolff, Antonio C.
影响因子：
4
作者：
de Prati, Alessandra Carcereri;Butturini, Elena;Mariotto, Sofia
通讯作者：
Mariotto, Sofia
影响因子：
168.9
作者：
Davies, C.;Godwin, J.;Gray, R.;Clarke, M.;Darby, S.;McGale, P.;Wang, Y. C.;Peto, R.;Pan, H. C.;Cutter, D.;Taylor, C.;Ingle, J.
通讯作者：
Ingle, J.
影响因子：
6.4
作者：
Busk, Morten;Horsman, Michael R.;Overgaard, Jens
通讯作者：
Overgaard, Jens