The Role of Krüppel-like Factor 4 in Renal Fibrosis.
The Role of Krüppel-like Factor 4 in Renal Fibrosis.
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Krüppel样因子4在肾纤维化中的作用。
DOI：
10.3389/fphys.2015.00327
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发表时间：
2015
影响因子：
4
通讯作者：
Fang X
中科院分区：
文献类型：
--
作者：
Ke B;Zhang A;Wu X;Fang X
由肾纤维化引起的慢性肾脏病（CKD）是一个重要的公共卫生问题。因此，有必要了解肾纤维化的分子发病机制，以开发新的治疗策略。KLF4是Krüppel样因子（KLF）家族中研究最广泛的因子。许多研究表明，KLF4抑制肌成纤维细胞的活化并对纤维化发挥抑制作用。然而，其他研究表明KLF4可能促进肾纤维化。这些有争议的结果表明，KLF4可能是至关重要的参与肾纤维化的发展，虽然（S）的潜在机制仍不清楚。本文就KLF4在肾纤维化中的作用作一综述。总之，这些发现表明KLF 4可能参与肾纤维化的发展，但其对纤维化的抑制作用大于其对病情的促进作用，这表明KLF 4可能作为肾纤维化的新治疗靶点。
Chronic kidney disease (CKD) caused by renal fibrosis is an important public health concern. It is therefore necessary to understand the molecular pathogenesis of renal fibrosis in order to develop novel therapeutic strategies. KLF4 is the most extensively studied factor among the various members of the Krüppel-like factor (KLF) family of zinc finger-containing transcription factors. Many studies have demonstrated that KLF4 inhibits the activation of myofibroblasts and exerts an inhibitory effect on fibrosis. However, other studies have indicated that KLF4 may promote renal fibrosis. These controversial results suggest that KLF4 may be crucially involved in the development of renal fibrosis, although the underlying mechanism(s) remain unclear. Here, we summarize the recent progress made in understanding the role of KLF4 in renal fibrosis. Together, these findings suggest that KLF4 may participate in the development of renal fibrosis, but that its inhibition of fibrosis is greater than its promotion of the condition, which suggests that KLF4 may serve as a novel therapeutic target for renal fibrosis.