Circulating Neutrophil-Derived Microparticles Associated with the Prognosis of Patients with Sepsis.
Circulating Neutrophil-Derived Microparticles Associated with the Prognosis of Patients with Sepsis.
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DOI：
10.2147/jir.s287256
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发表时间：
2020
影响因子：
4.5
通讯作者：
Ma D
中科院分区：
文献类型：
--
作者：
Chen HP;Wang XY;Pan XY;Hu WW;Cai ST;Joshi K;Deng LH;Ma D
由于其高发病率和死亡率，脓毒症仍然是ICU死亡的主要原因。微粒（MP）已被大量研究作为潜在的诊断或预后标志物在各种疾病，包括败血症。MP人群中嗜中性粒细胞衍生微粒（NDMP）的生物学和临床相关性仍不清楚。本研究的目的是阐明血浆NDMPs与脓毒症和/或脓毒性休克患者预后之间的关系。本研究设计为观察性、非干预性临床研究。本研究的队列包括分别于2018年1月至11月在广东省湛江市广东医科大学附属医院重症监护室（ICU）和健康监测中心住院的40例脓毒症和40例脓毒性休克患者以及10例健康对照。评估了脓毒症和脓毒性休克的危重疾病程度，并对2018年至2019年进行了数据分析。在入院后第1、3和5天，收集一系列数据，包括血浆TNF水平、患者人口统计学、TNF-α水平、IL-6水平、斯特雷姆-1水平和脓毒症严重程度评分测量值。针对血浆NDMP水平绘制存活曲线。在ICU入院后第1、3和5天，观察到脓毒性休克患者中的NDMP水平高于脓毒症患者（p < 0.05）。脓毒症和脓毒性休克患者的TNF-α水平显著升高，促炎介质和脓毒症严重程度评分（p < 0.05）以及死亡率平行增加。我们的数据表明，NDMPs可能是脓毒症严重程度和死亡率的生物标志物，但其对脓毒症预后的影响值得进一步研究。
Because of its high morbidity and mortality, sepsis remains the leading cause of death in the ICU. Microparticles (MP) have been largely studied as potential diagnostic or prognostic markers in various diseases including sepsis. The biological and clinical relevance of neutrophil-derived microparticles (NDMPs) within the MP population remains unclear. The objective of this study was to elucidate the relationship between plasma NDMPs and the prognosis of patients with sepsis and/or septic shock. The study was designed as an observational, noninterventional clinical study. The cohort for this study included 40 sepsis and 40 septic shock patients together with 10 healthy controls admitted to the Intensive Care Unit (ICU) and the Health Surveillance Center in the Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China, from January to November 2018, respectively. The degree of critical disease for sepsis and septic shock was evaluated, with data analyses conducted from 2018 to 2019. On days 1, 3 and 5 post-admission a series of data including plasma NDMP levels, patient demographics, TNF-α levels, IL-6 levels, sTREM-1 levels, and the sepsis severity score measurements were collected. A survival curve was plotted against levels of plasma NDMPs. Levels of NDMPs were observed to be higher in the septic shock patients than in the sepsis patients on days 1, 3, and 5 post-ICU admission (p < 0.05). NDMP levels were significantly increased in sepsis and septic shock patients with a parallel increase in pro-inflammatory mediators and sepsis severity score (p < 0.05) as well as mortality. Our data suggest that NDMPs may be a biomarker of sepsis severity and mortality although its implications on sepsis prognosis warrant further study.