A novel sesquiterpene derivative with a seven-membered B ring from Illigera aromatica.
A novel sesquiterpene derivative with a seven-membered B ring from Illigera aromatica.
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一种来自 Illigeraaromatica 的具有七元 B 环的新型倍半萜衍生物。
DOI：
10.1080/14786419.2018.1428596
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发表时间：
2018
影响因子：
2.2
通讯作者：
Ding Zhong Tao
中科院分区：
文献类型：
--
作者：
Dong Jian Wei;Cai Le;Li Xue Jiao;Shu Yan;Wang Jia Peng;Ding Zhong Tao
从芳香冬青中分得一个新的七元B环倍半萜衍生物--毛冬青碱（illigerine，1），沿着4个已知化合物，即1-表千叶素（1-epi-chiliophyllin，2），3，4-二羟基苯乙醇（3，4-dihydroxyphenethyl alcohol，3），松柏醇（coniferyl alcohol，4）和苯丙酸（phenylpropionic acid，5）。Z. Huang et S. L.密苏里州通过1D/2D NMR、HRESIMS和电子圆二色谱等方法对它们的结构进行了鉴定，并对LPS诱导的RAW264.7细胞的细胞毒活性和NO生成抑制作用进行了评价。这是首次从冬青属植物中分离得到倍半萜。
A novel sesquiterpene derivative with a seven-membered B ring, illigerine (1), along with four known compounds, 1-epi-chiliophyllin (2), 3,4-dihydroxyphenethyl alcohol (3), coniferyl alcohol (4) and phenylpropionic acid (5), were isolated fromIlligera aromaticaS. Z. Huang et S. L. Mo. Their structures were identified by 1D/2D NMR, HRESIMS and electronic circular dichroism spectra and the cytotoxic activity and inhibitory effect of NO production in LPS-stimulated RAW264.7 were also evaluated. This is the first report of sesquiterpene isolated from the genusIlligera.