TESTS OF THE HELIX DIPOLE MODEL FOR STABILIZATION OF ALPHA-HELICES
TESTS OF THE HELIX DIPOLE MODEL FOR STABILIZATION OF ALPHA-HELICES
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DOI：
10.1038/326563a0
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发表时间：
1987-04-09
期刊：
影响因子：
64.8
通讯作者：
BALDWIN, RL
中科院分区：
文献类型：
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作者：
SHOEMAKER, KR;KIM, PS;BALDWIN, RL
带电荷基团对分离的c肽（核糖核酸酶a残基1-13）在水溶液中形成的螺旋结构的稳定性起关键作用。在螺旋和螺旋偶极子两端的带电残基之间的相互作用可能产生一种带电基团效应。我们在这里报告了c肽类似物的研究支持螺旋偶极子模型，并进一步证明了静电相互作用对α-螺旋形成的重要性，而静电相互作用不包括在Zimm-Bragg模型中。
Charged groups play a critical role in the stability of the helix formed by the isolated C-peptide (residues 1–13 of ribonuclease A) in aqueous solution. One charged-group effect may arise from interactions between charged residues at either end of the helix and the helix dipole. We report here that studies of C-peptide analogues support the helix dipole model, and provide further evidence for the importance of electrostatic interactions not included in the Zimm–Bragg model for α-helix formation.