Profile of Free Fatty Acids and Fractions of Phospholipids, Cholesterol Esters and Triglycerides in Serum of Obese Youth with and without Metabolic Syndrome.
Profile of Free Fatty Acids and Fractions of Phospholipids, Cholesterol Esters and Triglycerides in Serum of Obese Youth with and without Metabolic Syndrome.
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DOI：
10.3390/nu8020054
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发表时间：
2016-02-15
期刊：
影响因子：
5.9
通讯作者：
Velásquez-Rodríguez C
中科院分区：
文献类型：
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作者：
Bermúdez-Cardona J;Velásquez-Rodríguez C
该研究评估了有和没有代谢综合征（MetS）的肥胖青年的循环脂肪酸（FA）谱，以确定其与营养状况，生活方式和代谢变量的关系。对96名青少年进行了横断面研究，分为三组：肥胖伴代谢综合征（OBMS）、肥胖（OB）和适当体重（AW）。通过气相色谱法定量FA谱;评估腰围（WC）、脂肪褶皱、血脂谱、高敏C反应蛋白、血糖、胰岛素、稳态模型评估（HOMA指数）、食物摄入和体力活动（PA）。OBMS组的总游离脂肪酸（FFA）、甘油三酯（TG）中的棕榈酸-16：0、TG和磷脂（PL）中的棕榈油酸-16：1 n-7显著更高;在OB组中，这些FA高于AW组。二高-γ-亚麻酸（DHGL-20：3 n-6）在OBMS中高于PL和FFA中的AW。OBMS组TG和PL中亚油酸-18：2n-6的比例最低。TG中的WC、PA、总FFA、亚油酸-18：2n-6和FFA中的DHGL-20：3 n-6可解释HOMA值的62%。OB组的FA和生化值的比例高于AW组。OBMS中TG、PL和FFA组分中部分FA的比例与MetS的紊乱相关。
The study evaluated the profile of circulating fatty acids (FA) in obese youth with and without metabolic syndrome (MetS) to determine its association with nutritional status, lifestyle and metabolic variables. A cross-sectional study was conducted in 96 young people, divided into three groups: obese with MetS (OBMS), obese (OB) and appropriate weight (AW). FA profiles were quantified by gas chromatography; waist circumference (WC), fat folds, lipid profile, high-sensitivity C-reactive protein, glucose, insulin, the homeostasis model assessment (HOMA index), food intake and physical activity (PA) were assessed. The OBMS group had significantly greater total free fatty acids (FFAs), palmitic-16:0 in triglyceride (TG), palmitoleic-16:1n-7 in TG and phospholipid (PL); in the OB group, these FAs were higher than in the AW group. Dihomo-gamma-linolenic (DHGL-20:3n-6) was higher in the OBMS than the AW in PL and FFAs. Linoleic-18:2n-6 in TG and PL had the lowest proportion in the OBMS group. WC, PA, total FFA, linoleic-18:2n-6 in TG and DHGL-20:3n-6 in FFAs explained 62% of the HOMA value. The OB group presented some higher proportions of FA and biochemical values than the AW group. The OBMS had proportions of some FA in the TG, PL and FFA fractions that correlated with disturbances of MetS.