Cell adhesion and invasion mechanisms that guide developing axons.
Cell adhesion and invasion mechanisms that guide developing axons.
复制标题
DOI：
10.1016/j.conb.2016.04.012
复制
发表时间：
2016-08
影响因子：
5.7
通讯作者：
Gomez TM
中科院分区：
文献类型：
--
作者：
Short CA;Suarez-Zayas EA;Gomez TM
轴突延伸、引导和组织侵袭与正常细胞迁移和癌细胞转移有许多相似之处。适当的细胞和生长锥迁移需要严格调控的粘附复合物组装和从细胞外基质（ECM）分离。此外，许多细胞类型使用基质金属蛋白酶（MMP）主动重塑ECM以控制组织侵入和细胞分散。靶向和激活MMP是一个严格调控的过程，当失调时，可能导致癌细胞转移。有趣的是，新的证据表明，生长锥表达类似的细胞和分子机制迁移细胞离合器逆行肌动蛋白流ECM蛋白和目标基质降解，这可能是用来促进轴突寻路通过基底层和跨组织。
Axon extension, guidance and tissue invasion share many similarities to normal cell migration and cancer cell metastasis. Proper cell and growth cone migration requires tightly regulated adhesion complex assembly and detachment from the extracellular matrix (ECM). In addition, many cell types actively remodel the ECM using matrix metalloproteases (MMPs) to control tissue invasion and cell dispersal. Targeting and activating MMPs is a tightly regulated process, that when dysregulated, can lead to cancer cell metastasis. Interestingly, new evidence suggests that growth cones express similar cellular and molecular machinery as migrating cells to clutch retrograde actin flow on ECM proteins and target matrix degradation, which may be used to facilitate axon pathfinding through the basal lamina and across tissues.