Experimental Infection of Japanese Encephalitis Virus in Dogs
Experimental Infection of Japanese Encephalitis Virus in Dogs
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DOI：
10.1292/jvms.11-0142
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发表时间：
2011-09-01
影响因子：
1.2
通讯作者：
Maeda, Ken
中科院分区：
文献类型：
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作者：
Shimoda, Hiroshi;Tamaru, Seiji;Maeda, Ken
先前对犬类进行的日本脑炎病毒（JEV）血清调查表明，犬类非常适合作为评估JEV向人类传播风险的哨兵。为观察犬的临床症状和抗乙脑病毒抗体持续时间，对3只犬进行乙脑病毒攻击实验。除c反应蛋白外，所有感染乙脑的小鼠均未表现出任何临床症状或血液检查异常。病毒中和滴度迅速增加并保持到感染后70天，血液中均未检测到病毒和病毒基因组。因此，由于它们作为伴侣动物与人类生活在很近的距离，它们非常适合作为哨兵来调查人类感染乙脑病毒的风险。
A previous serosurvey of Japanese encephalitis virus (JEV) among dogs suggested that dogs are well suited for use as sentinels for assessing the risk of JEV transmission to humans. To examine the clinical symptoms and duration of anti-JEV antibodies in dogs, three does were experimentally challenged with JEV. All JEV-infected does did not show any clinical signs or abnormal blood tests, except for C-reactive protein. Virus-neutralization titers rapidly increased and were maintained until 70 days postinfection, and neither the virus nor the viral genome was detected in blood. Thus, since does live in close proximity to humans as companion animals, they are well suited for use as sentinels for surveying the human risk of JEV infection.