Autophagy and autophagy-related pathways in cancer.
Autophagy and autophagy-related pathways in cancer.
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DOI：
10.1038/s41580-023-00585-z
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发表时间：
2023-08
期刊：
影响因子：
--
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蛋白质稳态和细胞器完整性和功能的维持对于细胞稳态和细胞活力至关重要。自噬是介导各种细胞货物递送到溶酶体进行降解和再循环的主要机制。无数的研究表明，自噬对疾病具有重要的保护作用。然而，在癌症中，自噬在预防早期肿瘤发展与维持和代谢适应已建立和转移的肿瘤中观察到似乎相反的作用。最近的研究不仅解决了自噬的肿瘤细胞内在功能，而且还解决了自噬在肿瘤微环境和相关免疫细胞中的作用。此外，已经描述了各种自噬相关的途径，其不同于经典的自噬，其利用自噬机制的一部分，并且可能导致恶性疾病。关于自噬和相关过程如何影响癌症发展和进展的越来越多的证据有助于指导设计基于抑制或促进自噬的抗癌治疗的努力。在这篇综述中，我们讨论和剖析了肿瘤发生、维持和进展过程中自噬和自噬相关过程的不同功能。我们概述了这些过程在肿瘤细胞和肿瘤微环境中的作用，并描述了针对癌症自噬过程的治疗进展。自噬可以起到肿瘤抑制和肿瘤促进的作用，通常取决于疾病阶段和突变背景。最近的研究结果推进了我们对自噬在癌细胞本身和肿瘤微环境中的这些看似相反的作用的理解。
Maintenance of protein homeostasis and organelle integrity and function is critical for cellular homeostasis and cell viability. Autophagy is the principal mechanism that mediates the delivery of various cellular cargoes to lysosomes for degradation and recycling. A myriad of studies demonstrate important protective roles for autophagy against disease. However, in cancer, seemingly opposing roles of autophagy are observed in the prevention of early tumour development versus the maintenance and metabolic adaptation of established and metastasizing tumours. Recent studies have addressed not only the tumour cell intrinsic functions of autophagy, but also the roles of autophagy in the tumour microenvironment and associated immune cells. In addition, various autophagy-related pathways have been described, which are distinct from classical autophagy, that utilize parts of the autophagic machinery and can potentially contribute to malignant disease. Growing evidence on how autophagy and related processes affect cancer development and progression has helped guide efforts to design anticancer treatments based on inhibition or promotion of autophagy. In this Review, we discuss and dissect these different functions of autophagy and autophagy-related processes during tumour development, maintenance and progression. We outline recent findings regarding the role of these processes in both the tumour cells and the tumour microenvironment and describe advances in therapy aimed at autophagy processes in cancer. Autophagy can serve both tumour-suppressive and tumour-promoting roles, often depending on disease stage and mutational background. Recent findings have advanced our understanding of these seemingly opposing roles of autophagy in cancer cells themselves and in the tumour microenvironment.
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DOI：
10.1146/annurev-pathmechdis-031521-022116
发表时间：
2023-01-24
期刊：
Annual review of pathology
影响因子：
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作者：
通讯作者：
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影响因子：
21.3
作者：
通讯作者：
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影响因子：
5.6
作者：
Chude CI;Amaravadi RK
通讯作者：
Amaravadi RK
DOI：
10.1073/pnas.1508541113
发表时间：
2016-02-16
影响因子：
11.1
作者：
Cheung, Kevin J.;Padmanaban, Veena;Ewald, Andrew J.
通讯作者：
Ewald, Andrew J.
影响因子：
11.4
作者：
Dupont, Nicolas;Jiang, Shanya;Deretic, Vojo
通讯作者：
Deretic, Vojo