Effects of sildenafil on maternal hemodynamics and fetal growth in normal rat pregnancy.
Effects of sildenafil on maternal hemodynamics and fetal growth in normal rat pregnancy.
复制标题
西地那非对正常妊娠大鼠母体血流动力学和胎儿生长的影响。
DOI：
10.1152/ajpregu.00198.2009
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Baylis,Chris
中科院分区：
文献类型：
--
作者：
Sasser,JenniferM;Baylis,Chris
It has been suggested that the phosphodiesterase-5 (PDE5) inhibitor sildenafil may be useful in the treatment of hypertension during pregnancy. However, we have reported a selective increase in renal inner medullary PDE5 that participates in the sodium retention of pregnancy. Therefore, the purpose of this study was to determine whether oral sildenafil treatment impairs maternal plasma volume expansion and/or fetal growth during rat pregnancy. Rats received sildenafil (10 mg·kg−1·day−1, 50 mg·kg−1·day−1, or 90 mg·kg−1·day−1) or vehicle ondays 4–20of pregnancy. Ondays 14–19, rats were housed in metabolic cages for collection of urine and measurement of food and water intake. Terminal hemodynamic and fetal measurements were taken onday 20. None of the sildenafil doses lowered blood pressure, and although all doses increased plasma cGMP concentrations, only the highest dose increased aortic and inner medullary cGMP content. Sildenafil had no effect on maternal weight gain; however, the highest dose decreased both plasma volume and renal sodium retention. The pup number and size were similar among the groups. Therefore, these studies suggest that low doses of systemic sildenafil may be safe during pregnancy in the rat, but higher doses may interfere with the physiological sodium retention and volume expansion of pregnancy. The effects of systemic sildenafil on blood pressure and sodium retention during hypertension in human pregnancy remain to be examined.
