Antibacterial and antifungal activities of novel hydroxytriazenes
Antibacterial and antifungal activities of novel hydroxytriazenes
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新型羟基三氮烯的抗菌和抗真菌活性
DOI：
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
Gichumbi
中科院分区：
文献类型：
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作者：
A. O. Ombaka;Muguna;Gichumbi
为了寻找新的先导化合物，合成了一系列新的羟基三氮烯类化合物i-xi，通过熔点、晶体形状、颜色和元素分析对其进行了表征，并采用比浊法对所合成的化合物进行了体外抗菌活性评价。试剂编号x和xi对两种革兰氏阳性菌[粪链球菌、金黄色葡萄球菌、青霉素耐药性（2500单位）]显示出显著的抗菌活性。所有合成的羟基三氮烯，除试剂号VIII显示抗真菌活性对五种真菌[白色念珠菌，新型隐球菌，申克孢子丝菌，毛癣菌mantagrophytes，烟曲霉}。对这些细菌和真菌的最小抑菌浓度（MIC）值范围为<12.5至50 µg/ml。一些羟基三氮烯（x，xi）显示出不寻常的组合抗菌和抗真菌作用，这表明羟基三氮烯揭示了广泛的抗菌活性。
关键词：抗菌，抗真菌，抗菌，羟基三氮烯，MIC，比浊。
In a search for new leads potent antimicrobial agents, an array of novel hydroxytriazenes i-xi were synthesized and characterized through their melting point, crystal shape, colour and elemental analysis. In vitro microbiological evaluations were carried out for all the synthesized compounds against both bacterial and fungi using the turbidimetric method. The reagent number x and xi showed significant antibacterial activities against two gram positive [Streptococcus feacalis, Staphylococcus aureus, penicillin resistance (2500 units)]. All synthesized hydroxytriazenes except reagent number viii showed antifungal activities against five fungi [Candida albicans, Cryptococcus neoformans, Sporotrichum schenckii, Trichophyton mantagrophytes, Aspergillus fumigatus}. The minimum inhibitory concentration (mic) values against these bacteria and fungi ranged from <12.5 to 50 µg/ml. Some hydroxytriazenes (x, xi) showed an unusual combined antibacterial and antifungal action, which suggest that hydroxytriazenes revealed a wide range of antimicrobial activity.
Key words: Antibacterial, antifungal, antimicrobial, hydroxytriazenes, mic, turbidimetric.