Higher Aortic Stiffness Is Associated With Lower Global Cerebrovascular Reserve Among Older Humans
Higher Aortic Stiffness Is Associated With Lower Global Cerebrovascular Reserve Among Older Humans
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DOI：
10.1161/hypertensionaha.118.11143
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发表时间：
2018-08-01
期刊：
影响因子：
8.3
通讯作者：
Pierce, Gary L.
中科院分区：
文献类型：
--
作者：
DuBose, Lyndsey E.;Ponto, Laura L. Boles;Pierce, Gary L.
随着人类年龄的增长，主动脉僵硬度和脉压增加与脑血管重塑、白色微结构减少和认知能力有关。然而，目前尚不清楚主动脉僵硬度和脉压是否与老年人基础全脑血流量（CBF）和脑血管储备减少有关。使用定量[O-15]水脑正电子发射断层扫描成像对205名成人（范围：19-87岁;平均值+/- SE：30.6 +/- 1.3岁）的总体CBF进行定量。在一个老年人亚组（n=24; 70.0 ± 2.0岁）中，评估了主动脉僵硬度（颈动脉股动脉脉搏波速度）和脑血管储备（乙酰唑胺静脉输注后总体CBF的变化）。在整个队列中，老年人的总体CBF低于年轻人（36.5 +/- 1.1 vs 50.5 +/- 0.7 mL/min/100 mL; P
Greater aortic stiffness and pulse pressure are associated with cerebrovascular remodeling, reduced white matter microstructure, and cognitive performance with aging in humans. However, it is unclear whether aortic stiffness and pulse pressure are associated with reduced basal global cerebral blood flow (CBF) and cerebrovascular reserve among older adults. Global CBF was quantified in 205 adults (range, 19-87 years; mean +/- SE: 30.6 +/- 1.3 years) using quantitative [O-15]water brain positron emission tomography imaging. In a subset of older adults (n=24; 70.0 +/- 2.0 years), aortic stiffness (carotid femoral pulse wave velocity) and cerebrovascular reserve (change in global CBF after intravenous infusion of acetazolamide) were assessed. In the entire cohort, global CBF was lower in older compared with young adults (36.5 +/- 1.1 versus 50.5 +/- 0.7 mL/min per 100 mL; P