Rare genetic variants in Shiga toxin-associated haemolytic uraemic syndrome: genetic analysis prior to transplantation is essential.
Rare genetic variants in Shiga toxin-associated haemolytic uraemic syndrome: genetic analysis prior to transplantation is essential.
复制标题
志贺毒素相关的溶血性尿毒症综合征中的罕见遗传变异：移植前的遗传分析是必不可少的。
DOI：
10.1093/ckj/sfx030
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发表时间：
2017-08
影响因子：
4.6
通讯作者：
Brocklebank V
中科院分区：
文献类型：
--
作者：
Dowen F;Wood K;Brown AL;Palfrey J;Kavanagh D;Brocklebank V
We present a case of haemolytic uraemic syndrome (HUS) in a 16-year-old female with serological evidence of acute Escherichia coli O157:H7 infection. She progressed to established renal failure and received a deceased donor kidney transplant. Shiga toxin–associated HUS (STEC-HUS) does not recur following renal transplantation, but unexpectedly this patient did experience rapid and severe HUS recurrence. She responded to treatment with the terminal complement inhibitor eculizumab and subsequent genetic analysis revealed a rare variant in a complement gene. This highlights the importance of genetic analysis in patients with STEC-HUS prior to renal transplantation so that management can be individualized.
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影响因子：
30.5
作者：
通讯作者：
--
影响因子：
6.1
作者：
Ahlenstiel-Grunow, Thurid;Hachmeister, Svenja;Pape, Lars
通讯作者：
Pape, Lars
影响因子：
2.8
作者：
Wong, Edwin;Challis, Rachel;Goodship, Timothy H. J.
通讯作者：
Goodship, Timothy H. J.
影响因子：
5.1
作者：
BRANDT, JR;FOUSER, LS;AVNER, ED
通讯作者：
AVNER, ED
影响因子：
13.6
作者：
Challis, Rachel C.;Araujo, Geisilaine S. R.;Kavanagh, David
通讯作者：
Kavanagh, David