Association between Poor Sleep Quality and Subsequent Peptic Ulcer Recurrence in Older Patients with Mild Cognitive Impairment: Examining the Role of Social Engagement
Association between Poor Sleep Quality and Subsequent Peptic Ulcer Recurrence in Older Patients with Mild Cognitive Impairment: Examining the Role of Social Engagement
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DOI：
10.1038/s41598-019-38715-3
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发表时间：
2019-02-18
影响因子：
4.6
通讯作者：
Chen, Gengzhen
中科院分区：
文献类型：
--
作者：
Fang, Boye;Yang, Shuyan;Chen, Gengzhen
本研究的目的是检查是否感知睡眠质量差预测随后复发的消化性溃疡病（PUD）的轻度认知功能障碍的老年患者幽门螺杆菌根除后，并调查是否社会参与状态改变这种关联。1,689例老年H. 2011 - 2014年从中华人民共和国8家三甲医院招募的幽门螺杆菌感染的PUD，H.到2014年底，1，538名患者根除了幽门螺杆菌并清除了PUD;其中1，420人随访长达36个月。Kaplan-Meier方法用于比较具有不同睡眠质量和社会参与状态的老年患者中经食管胃镜检查证实的PUD复发的比例。进行多变量Cox比例风险模型以检查睡眠质量和PUD复发之间的关联，以及社会参与在改变这种关系中的作用。结果表明，PUD复发率在睡眠不良者（10.8%）中高于睡眠良好者（5.5%）。然而，增加和持续的社会参与将睡眠不良者的比例分别降低到7.2%和8.2%。睡眠质量差与随后的PUD复发相关（风险比[HR] 1.965（1.002，3.518））。然而，在报告增加（HR 1.428（0.736，2.380））和持续（HR 1.273（0.915，2.492））社会参与的良好和不良睡眠者之间没有观察到显著差异，这表明增加和持续的社会参与阻止了睡眠质量差对PUD复发的影响。总之，睡眠质量差与随后的PUD复发有关。然而，增加和持续的社会参与可能会缓和这种关联。
This study aims to examine whether perceived poor sleep quality predicts subsequent recurrence of peptic ulcer disease (PUD) in older patients with mild cognitive impairment following Helicobacter pylori eradication and to investigate whether social engagement status alters this association. Of 1,689 older patients with H. pylori-infected PUD recruited from eight Grade-A hospitals in the People's Republic of China between 2011 and 2014, H. pylori was eradicated and PUD cleared in 1,538 patients by the end of 2014; 1,420 of these were followed for up to 36 months. The Kaplan-Meier method was used to compare the proportion of PUD recurrence, as confirmed with esophagogastroduodenoscopy, among older patients with different levels of sleep quality and social engagement statuses. Multivariate Cox-proportional hazards models were performed to examine the association between sleep quality and PUD recurrence, and the role of social engagement in altering this relationship. The results showed that PUD recurrence was more prevalent in poor (10.8%) compared with good sleepers (5.5%). However, increased and continued social engagement reduced the proportion to 7.2% and 8.2% among poor sleepers, respectively. Poor sleep quality was associated with subsequent PUD recurrence (hazard ratio [HR] 1.965 (1.002, 3.518)). However, no significant difference was observed between good and poor sleepers who reported increased (HR 1.428 (0.736, 2.380)) and continued (HR 1.273 (0.915, 2.492)) social engagement, suggesting that increased and continued social engagement prevented the effect of poor sleep quality on PUD recurrence. To conclude, poor sleep quality is associated with subsequent PUD recurrence. However, increased and continued social engagement may moderate this association.