The protective role of T cells in immunity to malaria.
The protective role of T cells in immunity to malaria.
复制标题
T 细胞在疟疾免疫中的保护作用。
DOI：
10.1007/978-1-4757-5421-6_11
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发表时间：
1988
影响因子：
--
通讯作者：
Long,CA
中科院分区：
文献类型：
--
作者：
Weidanz,WP;Brake,DA;Cavacini,LA;Long,CA
疟原虫属的成员具有复杂的生命周期，涉及脊椎动物和无脊椎动物宿主。在前者中，它们寄生于寄生虫，引起疟疾，这是一种以高发病率和全世界死亡率为特征的疾病。为了开发有效的疫苗来对抗这种疾病，研究主要集中在寄生虫的细胞外阶段，大概是因为它们应该比细胞内寄生虫更容易受到抗体依赖性抗性机制的影响。靶阶段包括孢子、配子和裂殖子。此外，表达于感染红细胞膜上的疟原虫抗体正被研究作为保护性抗体的潜在靶点。es. 1某些阶段特异性抗原已被鉴定并通过重组DNA技术表达或在实验室中生物化学合成，目前正在实验动物和人类中作为候选疫苗进行研究。相反，其他数据表明，除了抗体介导的免疫机制之外，疟原虫可以在细胞内发育过程中被免疫机制破坏。尽管定义这些免疫机制以及鉴定和表征负责其激活的寄生虫抗原的努力最近才开始，但它们可能为设计用于测试抗疟疾的其他免疫剂提供基础。在这篇文章中，我们将回顾某些证据，表明T细胞，除了作为辅助细胞在生产保护性抗体，发挥作用，
Members of the genus Plasmodium have a complex life cycle which involves both vertebrate and invertebrate hosts. In the former, they parasitize the erythron, causing malaria, a disease characterized by high morbidity and rr: ortality worldwide. In an effort to develop an effective vaccine to combat this disease, research has focused primarily on extracellular stages of the parasite presumably because they should be more accessible to antibody-dependent resistance mechanisms than intracellular parasites. Target stages include sporozoites, gametes, and merozoites. In addition, plasmodial antip; ens expressed on the membranes of infected erythrocytes are being studied as potential targets of protective antibodi. es. 1 Certain of the stage specific antigens which have been identified and expressed by recombinant DNA technology or synthesized biochemically in the laboratory are currently being investigated in experimental animals and humans as candidate 2-4 vaccines. In contrast, other data suggest that plasmodia can be destroyed dudng intracellular development by immune mechaI'isms apart from or in addition to those mediated by antibodies. 5~ Tllile efforts to define these immune mechanisms and to identify and characterize parasite antigens responsible for their activation have only recently begun, it is possible that they will provide a basis for the design of additional immunizing agents to be tested against malaria. In this article, we will review certain evidence that T cells, in addition to their function as helper cells in the production of protective antibodies, play an