Capstone Laboratory Experiment Investigating Key Features of Palladium-Catalyzed Suzuki–Miyaura Cross-Coupling Reactions
Capstone Laboratory Experiment Investigating Key Features of Palladium-Catalyzed Suzuki–Miyaura Cross-Coupling Reactions
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Capstone 实验室实验研究钯催化的 Suzuki-Miyaura 交叉偶联反应的关键特征
DOI：
10.1021/acs.jchemed.7b00964
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发表时间：
2018
影响因子：
3
通讯作者：
Alex C. Bissember
中科院分区：
文献类型：
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作者：
R. Pullen;A. Olding;Jason A. Smith;Alex C. Bissember
本实验分为两部分，主要研究铃木-宫浦交叉偶联反应的关键方面。本实验的第一部分利用高通量实验技术来加强，探索和扩展课堂上提出的基本概念。相比之下，第二部分采用引导探究学习策略，挑战学生设计，设置和执行一个模拟规模的铃木-宫浦反应，并建议后处理和隔离协议。通过设计，这个实验，这是在第三年的本科化学实验室课程进行的最后实验之一，作为学生的顶点学习经验。
This two-part laboratory experiment is concerned with investigating key aspects of the Suzuki–Miyaura cross-coupling reaction. The first part of this experiment utilizes high-throughput experimentation techniques to reinforce, explore, and extend fundamental concepts that are presented in the classroom. In contrast, the second part employs guided-inquiry learning strategies to challenge students to design, set up, and perform a preparative-scale Suzuki–Miyaura reaction and suggest workup and isolation protocols. By design, this experiment, which represents one of the final experiments performed in the third-year undergraduate chemistry laboratory program, serves as a capstone learning experience for students.