Antimicrobial use in European acute care hospitals: results from the second point prevalence survey (PPS) of healthcare-associated infections and antimicrobial use, 2016 to 2017.
Antimicrobial use in European acute care hospitals: results from the second point prevalence survey (PPS) of healthcare-associated infections and antimicrobial use, 2016 to 2017.
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DOI：
10.2807/1560-7917.es.23.46.1800393
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发表时间：
2018-11
期刊：
影响因子：
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通讯作者：
Point Prevalence Survey Study Group
中科院分区：
文献类型：
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作者：
Plachouras D;Kärki T;Hansen S;Hopkins S;Lyytikäinen O;Moro ML;Reilly J;Zarb P;Zingg W;Kinross P;Weist K;Monnet DL;Suetens C;Point Prevalence Survey Study Group
用于治疗感染的抗菌剂可以挽救生命。过度使用可能导致更频繁的不良反应和出现多重耐药微生物。2016-17年，我们在欧洲急性护理医院进行了第二次医疗相关感染（HAI）和抗菌药物使用的点患病率调查（PPS）。我们纳入了31个欧盟/欧洲经济区（EU/EEA）国家中的28个国家的1，209家医院和310，755名患者。欧盟/欧洲经济区抗菌药物使用的加权流行率为30.5%（95% CI：29.2-31.9%）。处方抗菌药物的最常见适应症是治疗社区获得性感染，其次是治疗HAI和手术预防。超过一半（54.2%）用于手术预防的抗菌药物的处方时间超过1天。使用抗菌药治疗的最常见感染是呼吸道感染，最常用的处方抗菌药物是青霉素和β-内酰胺酶抑制剂。在参与国家中，患者在抗菌药物、抗菌药物的选择以及抗菌药物管理资源和活动方面存在很大差异。PPS的结果提供了欧洲急性护理医院抗菌药物使用的详细信息，使国家和医院之间的比较成为可能，并突出了国家和欧洲行动的关键领域，这些行动将支持谨慎使用抗菌药物的努力。
Antimicrobial agents used to treat infections are life-saving. Overuse may result in more frequent adverse effects and emergence of multidrug-resistant microorganisms. In 2016–17, we performed the second point-prevalence survey (PPS) of healthcare-associated infections (HAIs) and antimicrobial use in European acute care hospitals. We included 1,209 hospitals and 310,755 patients in 28 of 31 European Union/European Economic Area (EU/EEA) countries. The weighted prevalence of antimicrobial use in the EU/EEA was 30.5% (95% CI: 29.2–31.9%). The most common indication for prescribing antimicrobials was treatment of a community-acquired infection, followed by treatment of HAI and surgical prophylaxis. Over half (54.2%) of antimicrobials for surgical prophylaxis were prescribed for more than 1 day. The most common infections treated by antimicrobials were respiratory tract infections and the most commonly prescribed antimicrobial agents were penicillins with beta-lactamase inhibitors. There was wide variation of patients on antimicrobials, in the selection of antimicrobial agents and in antimicrobial stewardship resources and activities across the participating countries. The results of the PPS provide detailed information on antimicrobial use in European acute care hospitals, enable comparisons between countries and hospitals, and highlight key areas for national and European action that will support efforts towards prudent use of antimicrobials.