A GENE FROM THE HUMAN SEX-DETERMINING REGION ENCODES A PROTEIN WITH HOMOLOGY TO A CONSERVED DNA-BINDING MOTIF
A GENE FROM THE HUMAN SEX-DETERMINING REGION ENCODES A PROTEIN WITH HOMOLOGY TO A CONSERVED DNA-BINDING MOTIF
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DOI：
10.1038/346240a0
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发表时间：
1990-07-19
期刊：
影响因子：
64.8
通讯作者：
GOODFELLOW, PN
中科院分区：
文献类型：
--
作者：
SINCLAIR, AH;BERTA, P;GOODFELLOW, PN
对男性性别决定所必需的人类 Y 染色体 35 kb 区域的搜索导致了一个新基因的鉴定。该基因在多种哺乳动物中是保守的且具有 Y 特异性，并编码睾丸特异性转录本。它与来自裂殖酵母粟酒裂殖酵母的交配型蛋白 Mc 以及核高迁移率蛋白 HMG1 和 HMG2 中存在的保守 DNA 结合基序具有同源性。该基因被称为 SRY（性别决定区 Y），并被提议作为难以捉摸的睾丸决定基因 TDF 的候选基因。
A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the identification of a new gene. This gene is conserved and Y-specific among a wide range of mammals, and encodes a testis-specific transcript. It shares homology with the mating-type protein, Mc, from the fission yeastSchizosaccharomyces pombeand a conserved DNA-binding motif present in the nuclear high-mobility-group proteins HMG1 and HMG2. This gene has been termedSRY(for sex-determining region Y) and proposed to be a candidate for the elusive testis-determining gene,TDF.