Host response to xenograft ECM implantation is not different between the shoulder and body wall sites in the rat model.
Host response to xenograft ECM implantation is not different between the shoulder and body wall sites in the rat model.
复制标题
在大鼠模型中，宿主对异种移植物 ECM 植入的反应在肩部和体壁部位之间没有差异。
DOI：
10.1002/jor.22149
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Derwin,KathleenA
中科院分区：
文献类型：
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作者：
Leigh,DianeR;Mesiha,Mena;Baker,AndrewR;Walker,Esteban;Derwin,KathleenA
在肌腱和韧带修复的背景下，已知机械载荷和关节滑液的存在深刻影响修复组织的形式和功能，并可能影响宿主对生物材料的反应。以前，我们证明了异种移植物细胞外基质（ECM）支架植入大鼠肩部引起了独特的主机从体壁中看到的反应。然而，宿主对植入肌腱/关节囊损伤肩部的异种移植物的反应与植入无损伤肩部的异种移植物无差异。在目前的研究中，我们假设不同的临床相关手术和环境因素会导致宿主对肩部异种移植物植入反应的显著差异。与我们的假设相反，我们发现在大鼠模型中，任何肩关节植入条件之间或肩关节和体壁植入之间的宿主反应没有显著差异。这些发现表明，在大鼠模型中使用原位肩关节模型来研究宿主对肩袖支架材料的反应没有优势，并且由于其宿主反应对各种临床相关手术条件不敏感，可能表明大鼠不能提供直接将宿主对生物材料的反应转化为人类应用的替代物。© 2012骨科研究学会。出版社：Wiley Periodicals，Inc. J Orthop Res 30：1725-1731，2012
In the context of tendon and ligament repair, mechanical loading and the presence of joint synovial fluid are known to profoundly influence the form and function of the repair tissue and potentially the host response to biomaterials. Previously, we demonstrated that a xenograft extra cellular matrix (ECM) scaffold implanted in the rat shoulder elicited a unique host response from that seen in the body wall. However, the host response to xenografts implanted in shoulders with a tendon/capsule injury was not different from xenografts implanted in shoulders with no injury. In the current study, we hypothesized that varying clinically relevant surgical and environmental factors would introduce significant differences in host response to xenograft implantation at the shoulder. Contrary to our hypothesis, we found no significant differences in host response between any shoulder implantation conditions or between shoulder and body wall implantation in the rat model. These findings suggest that there is no advantage to using an orthotopic shoulder model to investigate the host response to rotator cuff scaffold materials in the rat model, and due to the insensitivity of its host response to various clinically relevant surgical conditions, may suggest that the rat does not provide a surrogate for directly translating the host response to biomaterials to the human application. © 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 30:1725–1731, 2012