Clinical Usefulness of Endometrial Cytology in Determining the Therapeutic Effect of Fertility Preserving Therapy
Clinical Usefulness of Endometrial Cytology in Determining the Therapeutic Effect of Fertility Preserving Therapy
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子宫内膜细胞学检查在确定生育力保留疗法治疗效果中的临床应用
DOI：
10.1159/000520701
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发表时间：
2022
期刊：
影响因子：
1.8
通讯作者：
Aoki D.
中科院分区：
文献类型：
--
作者：
Yoshimura T.;Yamagami W.;Takahashi M.;Hirano T.;Sakai K.;Makabe T.;Chiyoda T.;Banno K.;Aoki D.
简介：子宫内膜细胞学检查在确定醋酸甲羟孕酮（MPA）治疗效果中的意义尚不清楚。本研究旨在评价子宫内膜细胞学检查在MPA治疗过程中的临床实用性。方法：回顾性分析2018年1月至2019年12月期间在我院接受刮宫术（D&C）评估MPA治疗效果的77例患者。根据患者病历对D&C结果、细胞学评估和其他临床病理因素进行分析。结果：细胞学检查的敏感性和特异性分别为61%和92%，在142例D&C/细胞学检查中，D&C是诊断的金标准。在 D&C 上无残留疾病的患者中，5 名 (4%) 的细胞学检查结果可疑或呈阳性。尽管其中3例患者终止了MPA治疗，但只有1例患者出现早期复发，且复发频率与D&C和细胞学结果均为阴性的患者相似。讨论/结论：子宫内膜细胞学检查在确定MPA治疗效果方面的敏感性较低，我们证实遗漏D&C是不可接受的。我们的研究结果还表明，在 MPA 治疗期间在 D&C 中添加细胞学评估的临床意义较低。
Introduction:The significance of endometrial cytology in determining the therapeutic efficacy of medroxyprogesterone acetate (MPA) therapy is unclear. This study aimed to evaluate the clinical usefulness of endometrial cytology during MPA therapy.Methods:Overall, 77 patients who underwent dilatation and curettage (D&C) to evaluate the therapeutic efficacy of MPA therapy at our hospital between January 2018 and December 2019 were retrospectively analyzed. The results of D&C, cytological evaluation, and other clinicopathological factors were analyzed based on the patients’ medical records.Results:The sensitivity and specificity of cytology were 61% and 92%, respectively, with D&C being the gold standard for diagnosis in 142 D&C/cytological examinations. Among patients with no residual disease on D&C, 5 (4%) had suspicious or positive cytology. Although MPA therapy was terminated in 3 of these patients, only 1 patient had early recurrence, and the frequency of recurrence was similar to that of patients who showed negative results in both D&C and cytology.Discussion/Conclusion:The sensitivity of endometrial cytology in determining the therapeutic effect of MPA therapy is low, and we confirmed that the omission of D&C is unacceptable. Our findings also suggested that the addition of cytological evaluation to D&C during MPA therapy had a low clinical significance.
影响因子：
3.5
作者：
Fujiwara, Hiroyuki;Takahashi, Yoshifumi;Suzuki, Mitsuaki
通讯作者：
Suzuki, Mitsuaki
DOI：
--
发表时间：
2019
期刊：
--
影响因子：
--
作者：
Doreen Agnese;Kimberly H. Allison;Sarah L. Blair;H. Burstein;Anthony D. Elias;Sharon H. Giordano
通讯作者：
Doreen Agnese;Kimberly H. Allison;Sarah L. Blair;H. Burstein;Anthony D. Elias;Sharon H. Giordano
影响因子：
4.8
作者：
Concin, Nicole;Matias-Guiu, Xavier;Creutzberg, Carien L.
通讯作者：
Creutzberg, Carien L.