The Exosome: a New Player in Diabetic Cardiomyopathy

The Exosome: a New Player in Diabetic Cardiomyopathy
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外泌体:糖尿病心肌病的新参与者

DOI:
10.1007/s12265-018-9825-x
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发表时间:
2018-09
影响因子:
3.4
通讯作者:
Hua Fei
Hua Fei
中科院分区:
医学3区
文献类型:
--
作者:
Tao Lichan;Shi Jia;Yang Xiaoyu;Yang Ling;Hua Fei

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糖尿病性心肌病(DCM)或糖尿病引起的心功能障碍是不受控制的代谢综合征的直接后果,并在世界范围内发生。然而,潜在的细胞和分子机制仍然知之甚少。最近,外泌体作为生物分子或药物治疗的高效、靶向和非免疫原性递送系统引起了相当大的兴趣。本文综述了外泌体在DCM中的调控和功能的快速发展,为现代人类健康与糖尿病相关的心脏疾病的防治提供有价值的见解和治疗机会。
Diabetic cardiomyopathy (DCM) or diabetes-induced cardiac dysfunction is a direct consequence of uncontrolled metabolic syndrome and occurs worldwide. However, the underlying cellular and molecular mechanisms remain poorly understood. Recently, exosomes have attracted considerable interest for their use as efficient, targeted, and non-immunogenic delivery systems for biological molecules or pharmacotherapies. This review will summarize the fast-developing field of the regulation and function of exosomes in DCM, affording valuable insights and therapeutic opportunities in combatting diabetes-related cardiac disorder for modern human health.
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