Spectrum of subepidermal immunobullous disorders seen at the National Skin Centre, Singapore: a 2-year review
Spectrum of subepidermal immunobullous disorders seen at the National Skin Centre, Singapore: a 2-year review
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DOI：
10.1046/j.1365-2133.2002.04919.x
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发表时间：
2002-09-01
影响因子：
10.3
通讯作者：
Chua, SH
中科院分区：
文献类型：
--
作者：
Wong, SN;Chua, SH
表皮下免疫大疱性疾病（SEIBD）包括大疱性类天疱疮（BP）、瘢痕性类天疱疮（CP）、获得性大疱性表皮炎（EBA）、线状伊加病（LAD）、疱疹样皮炎（DH）、妊娠类天疱疮（PG）和大疱性系统性红斑狼疮（BSLE）。他们被认为是罕见的，在远东地区比在西欧。Objectives这2年的回顾性研究调查的频谱看到，在我们的中心和最低估计发病率each.Patients和方法A共67例，在国家皮肤中心（NSC），新加坡1998年1月和1999年12月之间被诊断为有SEIBD。59例（88%）有BP，4例（6%）有EBA，2例（3%）LAD和2例（3%）BSLE。在此期间没有诊断出CP、DH或PG病例。我们当地人群的最低估计发病率分别为每年每百万人口7.6、0.5、0.26和0.26。平均发病年龄分别为77、68、65和31岁。结果BP是当地最常见的SEIBD，其发病率至少与西欧相当。在我们的中心，它的诊断频率是天疱疮的三倍。有一种对华人的偏爱，而不是印度人。EBA是西欧的两倍，并显示出对印第安人的偏爱。与中国相比，LAD在这里很少见，尽管中国人口占主导地位。BSLE也很罕见。与西欧相反，CP、DH和PG在新加坡非常罕见。结论这是该地区的第一项研究表明，某些SEIBD在远东并不像以前认为的那样更罕见。
Background The subepidermal immunobullous disorders (SEIBDs) comprise bullous pemphigoid (BP), cicatricial pemphigoid (CP), epidermolysis bullosa acquisita (EBA), linear IgA disease (LAD), dermatitis herpetiformis (DH), pemphigoid gestationis (PG) and bullous systemic lupus erythematosus (BSLE). They are thought to be rarer in the Far East than in western Europe.Objectives This 2-year retrospective study investigates the spectrum seen at our centre and the minimum estimated incidence of each.Patients and methods A total of 67 patients seen at the National Skin Centre (NSC), Singapore between January 1998 and December 1999 were diagnosed as having an SEIBD. Fifty-nine (88%) had BP, four (6%) had EBA, two (3%) LAD and two (3%) BSLE. There were no cases of CP, DH or PG diagnosed during this period. The minimum estimated incidence in our local population was 7.6, 0.5, 0.26 and 0.26 per million population per year, respectively. The mean age of onset was 77, 68, 65 and 31 years, respectively.Results BP is the commonest SEIBD seen locally, with an incidence at least equal to that in western Europe. It is diagnosed at our centre three times more frequently than pemphigus. There is a predilection for ethnic Chinese but not Indian. EBA is twice as common as in western Europe and shows a predilection for ethnic Indians. LAD is rare here compared to China, despite the predominant Chinese population. BSLE is also rare. In contrast to western Europe, CP, DH and PG are very rare in Singapore.Conclusions This is the first study from this region to show that certain SEIBDs are not rarer in the Far East, as previously thought.