Oxytocin-Oxytocin Receptor Systems Facilitate Social Defeat Posture in Male Mice
Oxytocin-Oxytocin Receptor Systems Facilitate Social Defeat Posture in Male Mice
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DOI：
10.1210/en.2017-00606
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发表时间：
2018-02-01
期刊：
影响因子：
4.8
通讯作者：
Onaka, Tatsushi
中科院分区：
文献类型：
--
作者：
Nasanbuyan, Naranbat;Yoshida, Masahide;Onaka, Tatsushi
社会压力对各种精神疾病有恶化的影响。在动物模型中，暴露于社会优势同质性(即，社会失败压力)会通过未知的机制唤起物种特有的失败姿势。催产素神经元已被证明被应激刺激激活，并具有亲社会和缓解焦虑的作用。催产素在社会失败压力中的作用尚不清楚。神经元活化标志c-Fos在催产素神经元和催产素受体中的表达在小鼠体内观察神经元的表达情况。用顺行病毒示踪剂检测催产素神经元的投射，这种病毒示踪剂诱导催产素神经元选择性表达膜靶向棕榈酰化绿色荧光蛋白。催产素受体双重暴露于社会失败应激时的防御行为。对缺陷小鼠进行分析。社会失败应激后，催产素神经元在终纹床核、视上核和下丘脑室旁核的c-Fos蛋白表达增加。催产素受体c-Fos蛋白表达增加。脑区神经元的表达，包括下丘脑腹内侧部和中脑导水管周围灰质的腹外侧部。下丘脑室旁核催产素神经元的投射纤维位于下丘脑腹内侧部和中脑导水管周围灰质的腹外侧部。催产素受体。在第二次社会失败应激中，缺陷小鼠的失败姿势有所减少。这些发现表明，社会失败应激激活催产素-催产素受体系统，这一发现与如下观点一致，即大脑区域，包括下丘脑腹内侧部和中脑导水管周围灰质腹外侧部，催产素受体的激活促进了社会失败姿势的形成。
Social stress has deteriorating effects on various psychiatric diseases. In animal models, exposure to socially dominant conspecifics (i.e., social defeat stress) evokes a species-specific defeat posture via unknown mechanisms. Oxytocin neurons have been shown to be activated by stressful stimuli and to have prosocial and anxiolytic actions. The roles of oxytocin during social defeat stress remain unclear. Expression of c-Fos, a marker of neuronal activation, in oxytocin neurons and in oxytocin receptor. expressing neurons was investigated in mice. The projection of oxytocin neurons was examined with an anterograde viral tracer, which induces selective expression of membrane-targeted palmitoylated green fluorescent protein in oxytocin neurons. Defensive behaviors during double exposure to social defeat stress in oxytocin receptor. deficient mice were analyzed. After social defeat stress, expression of c-Fos protein was increased in oxytocin neurons of the bed nucleus of the stria terminalis, supraoptic nucleus, and paraventricular hypothalamic nucleus. Expression of c-Fos protein was also increased in oxytocin receptor. expressing neurons of brain regions, including the ventrolateral part of the ventromedial hypothalamus and ventrolateral periaqueductal gray. Projecting fibers from paraventricular hypothalamic oxytocin neurons were found in the ventrolateral part of the ventromedial hypothalamus and in the ventrolateral periaqueductal gray. Oxytocin receptor. deficient mice showed reduced defeat posture during the second social defeat stress. These findings suggest that social defeat stress activates oxytocin-oxytocin receptor systems, and the findings are consistent with the view that activation of the oxytocin receptor in brain regions, including the ventrolateral part of the ventromedial hypothalamus and the ventrolateral periaqueductal gray, facilitates social defeat posture.