Anti‐viral effects of interferon‐λ3 on hepatitis B virus infection in cell culture
Anti‐viral effects of interferon‐λ3 on hepatitis B virus infection in cell culture
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DOI：
10.1111/hepr.13449
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发表时间：
2019-11
影响因子：
4.2
通讯作者：
N. Yamada;Asako Murayama;M. Shiina;Hussein H. Aly;Masashi Iwamoto;Senko Tsukuda;Koichi Watashi;Tomohisa Tanaka;K. Moriishi;H. Nishitsuji;M. Sugiyama;M. Mizokami;K. Shimotohno;M. Muramatsu;K. Murata;Takanobu Kato
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文献类型：
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作者：
N. Yamada;Asako Murayama;M. Shiina;Hussein H. Aly;Masashi Iwamoto;Senko Tsukuda;Koichi Watashi;Tomohisa Tanaka;K. Moriishi;H. Nishitsuji;M. Sugiyama;M. Mizokami;K. Shimotohno;M. Muramatsu;K. Murata;Takanobu Kato
已知干扰素（IFN）-λ3对各种病原体具有抗病毒作用。最近，有报道称，在给予核苷酸类似物后，结肠细胞中IFN-λ3的产生有望减少慢性B型肝炎患者的B型肝炎表面抗原。在此，我们旨在通过使用体外HBV生产和感染系统来证明IFN-λ3对B型肝炎病毒（HBV）的抗病毒作用。
Interferon (IFN)‐λ3 is known to have antiviral effects against various pathogens. Recently, it has been reported that the production of IFN‐λ3 in colon cells after the administration of nucleotide analogs is expected to reduce hepatitis B surface antigen in chronic hepatitis B patients. Here, we aimed to prove the antiviral effects of IFN‐λ3 on hepatitis B virus (HBV) by using an in vitro HBV production and infection system.