Clinical significance of CD155 expression in human pancreatic cancer.
Clinical significance of CD155 expression in human pancreatic cancer.
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发表时间：
2015-04
影响因子：
2
通讯作者：
S. Nishiwada;M. Sho;S. Yasuda;K. Shimada;I. Yamato;T. Akahori;Shoichi Kinoshita;M. Nagai;N. Konishi;Y. Nakajima
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文献类型：
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作者：
S. Nishiwada;M. Sho;S. Yasuda;K. Shimada;I. Yamato;T. Akahori;Shoichi Kinoshita;M. Nagai;N. Konishi;Y. Nakajima
背景/目的CD155在多种类型的人类细胞中表达，具有多种功能。在此，我们评估了CD155在胰腺癌中的临床重要性。材料与方法检测134例胰腺癌组织中CD155的表达，探讨CD155与胰腺癌预后、肿瘤免疫功能及血管生成的关系。此外，还检测了CD155的功能。结果CD155在胰腺癌组织中大量表达。CD155高表达患者术后预后比低表达患者差。多因素分析显示，CD155表达具有显著的独立预后价值。肿瘤CD155的表达与肿瘤浸润性淋巴细胞的存在呈负相关。此外，它与血管内皮生长因子的表达和肿瘤内微血管密度呈显著正相关。此外，CD155的沉默抑制了胰腺癌细胞的增殖，并诱导细胞周期停滞于G2/M期。结论CD155可能通过免疫学和非免疫学机制在胰腺癌中发挥重要作用，有可能成为治疗胰腺癌的靶点。
BACKGROUND/AIM CD155 is expressed in many types of human cells and has diverse functions. We herein evaluated the clinical importance of CD155 in pancreatic cancer. MATERIALS AND METHODS We investigated CD155 expression in 134 patients with pancreatic cancer, and evaluated the correlations of CD155 with prognosis, tumor immunity and angiogenesis. Furthermore, CD155 functions were examined. RESULTS CD155 expression was abundant in pancreatic cancer tissues. Patients with high CD155 expression had poorer postoperative prognosis than those with low expression. Multivariate analysis indicated that CD155 expression had a significant independent prognostic value. Tumor CD155 expression inversely correlated with the presence of tumor-infiltrating lymphocytes. Furthermore, it significantly positively correlated with vascular endothelial growth factor expression and intra tumoral microvessel density. In addition, silencing of CD155 inhibited proliferation, and induced cell-cycle arrest at G2/M phase in pancreatic cancer cells. CONCLUSION CD155 may play a critical role through both immunological and non-immuno logical mechanisms in pancreatic cancer and may be a therapeutic target for this intractable malignancy.