INCREASED PLASMA-LEVELS OF A RAPID INHIBITOR OF TISSUE PLASMINOGEN-ACTIVATOR IN YOUNG SURVIVORS OF MYOCARDIAL-INFARCTION
INCREASED PLASMA-LEVELS OF A RAPID INHIBITOR OF TISSUE PLASMINOGEN-ACTIVATOR IN YOUNG SURVIVORS OF MYOCARDIAL-INFARCTION
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DOI：
10.1056/nejm198512193132501
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发表时间：
1985-01-01
影响因子：
158.5
通讯作者：
BLOMBACK, M
中科院分区：
文献类型：
--
作者：
HAMSTEN, A;WIMAN, B;BLOMBACK, M
心肌梗塞的某些危险因素与纤溶活性紊乱有关。我们实验室最近开发了用于测定组织纤溶酶原激活剂 (t-PA) 活性和抗原的新的敏感和特异方法，以及发现了这种酶的新型快速抑制剂，使我们能够详细研究代表性梗塞后患者群体的纤溶功能。研究人员将 72 名 45 岁之前心肌梗塞幸存的患者（62 名男性和 9 名女性）与梗塞发生三年后的 50 名年龄相近的健康受试者进行了比较。静脉闭塞后 t-PA 活性低，主要是由于 t-PA 抑制剂血浆浓度高，在一定程度上是由于血管壁 t-PA 释放受损，这是患者中常见的现象。 t-PA抑制剂水平与血清甘油三酯水平呈显着正相关。我们的数据表明，由于 t-PA 快速抑制剂血浆水平升高而导致纤溶能力降低，可能在心肌梗死中具有重要的发病机制，特别是在高甘油三酯血症患者中。
Certain risk factors for myocardial infarction have been linked with disturbances in fibrinolytic activity. The recent development in our laboratory of new sensitive and specific methods for determination of tissue plasminogen activator (t-PA) activity and antigen, as well as the discovery of a new rapid inhibitor of this enzyme, enabled us to study fibrinolytic function in detail in a representative population of postinfarction patients. Seventy-two patients (62 men and 9 women) who had survived a myocardial infarction before the age of 45 were compared with 50 healthy subjects of similar age, three years after the infarction. Low t-PA activity after venous occlusion, mostly explained by high plasma levels of the t-PA inhibitor and to some extent by impaired release of t-PA from the vessel wall, was a frequent finding in the patients. The level of t-PA inhibitor was positively and significantly correlated with levels of serum triglycerides. Our data suggest that reduced fibrinolytic capacity due to increased plasma levels of a rapid inhibitor of t-PA may have pathogenetic importance in myocardial infarction particularly in patients with hypertriglyceridemia.