An association between non-gonococcal urethritis and bacterial vaginosis and the implications for patients and their sexual partners.
An association between non-gonococcal urethritis and bacterial vaginosis and the implications for patients and their sexual partners.
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非淋菌性尿道炎和细菌性阴道病之间的关联及其对患者及其性伴侣的影响。
DOI：
10.1136/sti.73.5.373
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
David Taylor
中科院分区：
文献类型：
--
作者：
F. Keane;B. Thomas;L. Whitaker;Adrian Renton;David Taylor
目的：相当比例男性非淋菌性尿道炎（NGU）的病因仍未明确。我们希望研究细菌性阴道病（BV）在这种疾病中的可能病因作用，BV是女性异常分泌物的最常见病因。
方法：我们进行了两项研究。在第一项病例对照研究中，我们招募了患有和未患有NGU的男性，并检查他们的女性伴侣是否有BV的证据。第二项队列设计研究与第一项研究同时进行，涉及招募患有和未患有BV的女性，并检查她们的男性伴侣是否有NGU的证据。NGU和BV的诊断均通过显微镜检查做出，包括两种疾病类别中的有症状和无症状个体。
结果：在病例对照研究中，招募了51对夫妇。其中39名男性患有NGU，他们的女性伴侣中有12人（31%）患有BV。相比之下，在12名未患NGU的男性中，只有1名（8%）女性伴侣患有BV（优势比为4.89，95%置信区间：0.51 - 42.27）。当仅考虑沙眼衣原体阴性患者时，BV与NGU之间关联的优势比增加到6.77，95%置信区间：0.73 - 62.68。38对夫妇被招募到队列设计研究中。在17名患有BV的女性中，她们的男性伴侣中有12人（71%）患有NGU。相比之下，在21名未患BV的女性中，她们的男性伴侣中有7人（33%）患有NGU（p = 0.049，优势比为4.8）。当仅考虑沙眼衣原体阴性患者时，关联的显著性增加（p = 0.037；优势比为5.42）。
结论：NGU和BV之间存在关联，反之亦然。如果BV是新发的，这些发现可能有助于解释稳定性关系中尿道炎的发生。
OBJECTIVES: The aetiology of non-gonococcal urethritis (NGU) in a considerable proportion of men remains unaccounted for. We wished to investigate the possible aetiological role of bacterial vaginosis (BV), the commonest cause of abnormal discharge in women, in this condition. METHODS: We carried out two studies. In the first, case-control, study, we recruited men with and without NGU and examined their female partners for evidence of BV. The second, cohort design, study which ran concurrently with the first study involved recruiting women with and without BV and examining their male partners for evidence of NGU. The diagnoses of both NGU and BV were made microscopically to include symptomatic and asymptomatic individuals in both disease categories. RESULTS: In the case-control study 51 couples were recruited. Of these 39 men had NGU and 12 (31%) of their female contacts had BV. In contrast, of 12 men without NGU, only one (8%) of the female partners had BV (odds ratio 4.89, 95% CI: 0.51-42.27). When only Chlamydia trachomatis negative patients were considered, the odds ratio for an association between BV and NGU was increased to 6.77, 95% CI: 0.73-62.68). Thirty eight couples were recruited to the cohort design study. Of 17 women with BV, 12 (71%) of their male partners had NGU. In contrast, of 21 women without BV, seven (33%) of their male partners had NGU (p = 0.049, odds ratio 4.8). When only C trachomatis negative patients were considered, the significance of the association was increased (p = 0.037; odds ratio 5.42). CONCLUSIONS: An association exists between NGU and BV, and vice versa. If BV arises de novo the findings could help to explain the development of urethritis in stable sexual relationships.