Characterization of CD56-/CD16+ natural killer (NK) cells:: A highly dysfunctional NK subset expanded in HIV-infected viremic individuals
Characterization of CD56-/CD16+ natural killer (NK) cells:: A highly dysfunctional NK subset expanded in HIV-infected viremic individuals
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DOI：
10.1073/pnas.0409872102
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发表时间：
2005-02-22
影响因子：
11.1
通讯作者：
Fauci, AS
中科院分区：
文献类型：
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作者：
Mavilio, D;Lombardo, G;Fauci, AS
自然杀伤 (NK) 细胞是针对病毒感染的先天免疫反应的重要组成部分。在病毒复制水平较高的 HIV 感染者中，INK 细胞介导的溶细胞活性存在缺陷。在本研究中，我们检查了一种不寻常的CD56(-)/CD16(+) (CD56(-)) NK亚群的表型和功能特征，该亚群在HIV病毒血症个体中大大扩展。与 CD56(+) NK 细胞相比，CD56-INK 部分中观察到的抑制性 INK 受体表达水平较高，天然细胞毒性受体表达水平较低，这与该亚群体外细胞毒功能极差有关。此外，与 CD56+ NK 细胞亚群相比，CD56- 中已知对启动抗病毒免疫反应很重要的某些细胞因子的分泌显着减少。这些数据表明，这种高度功能失调的CD56-NK细胞亚群在HIV病毒血症个体中的扩张在很大程度上解释了总INK细胞群的功能受损。
Natural killer (NK) cells are an important component of the innate immune response against viral infections. INK cell-mediated cytolytic activity is defective in HIV-infected individuals with high levels of viral replication. In the present study, we examined the phenotypic and functional characteristics of an unusual CD56(-)/CD16(+) (CD56(-)) NK subset that is greatly expanded in HIV-viremic individuals. The higher level of expression of inhibitory INK receptors and the lower level of expression of natural cytotoxicity receptors observed in the CD56- INK fraction compared with that of CD56(+) NK cells was associated with extremely poor in vitro cytotoxic function of this subset. in addition, the secretion of certain cytokines known to be important in initiating antiviral immune responses was markedly reduced in the CD56-, as compared with the CD56+ NK cell subset. These data suggest that the expansion of this highly dysfunctional CD56- NK cell subset in HIV-viremic individuals largely accounts for the impaired function of the total INK cell population.