Vascular metallomics: copper in the vasculature.
Vascular metallomics: copper in the vasculature.
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DOI：
10.1177/1358863x09346656
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发表时间：
2010-02
期刊：
影响因子：
--
通讯作者：
Zhenyu Qin
中科院分区：
文献类型：
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作者：
Easter RN;Qilin Chan;Lai B;Ritman EL;Caruso JA;Zhenyu Qin
由于分析技术的最新进展，金属组学正在从检测特定状态下的不同痕量金属发展到监测体外和体内痕量金属丰度和位置的动态变化。血管金属组学是研究微量金属在脉管系统中的作用的新兴领域。本综述将介绍常见的金属组学技术，包括原子吸收光谱法、电感耦合等离子体原子发射光谱法、电感耦合等离子体质谱法和X射线荧光光谱法，并提供总结表来比较这些技术。此外，我们将总结最近将这些技术应用于心血管疾病人群研究的研究结果，特别强调铜在这些疾病中的作用。为了解决金属组学和血管生物学之间的跨学科研究问题，我们将回顾了解铜在新生血管形成中的作用的努力进展。金属组学领域的最新进展可能是阐明这些微量金属的信号传导途径和特定生物功能的有力工具。最后，我们总结了支持铜是动态信号分子这一观点的证据。作为未来的方向，血管金属组学研究可能有助于确定心血管疾病诊断和治疗的靶点。
Due to recent progress in analytical techniques, metallomics are evolving from detecting distinct trace metals in a defined state to monitoring the dynamic changes in the abundance and location of trace metals in vitro and in vivo. Vascular metallomics is an emerging field that studies the role of trace metals in vasculature. This review will introduce common metallomics techniques including atomic absorption spectrometry, inductively coupled plasma-atomic emission spectrometry, inductively coupled plasma-mass spectrometry and X-ray fluorescence spectrometry with a summary table to compare these techniques. Moreover, we will summarize recent research findings that have applied these techniques to human population studies in cardiovascular diseases, with a particular emphasis on the role of copper in these diseases. In order to address the issue of interdisciplinary studies between metallomics and vascular biology, we will review the progress of efforts to understand the role of copper in neovascularization. This recent progress in the metallomics field may be a powerful tool to elucidating the signaling pathways and specific biological functions of these trace metals. Finally, we summarize the evidence to support the notion that copper is a dynamic signaling molecule. As a future direction, vascular metallomics studies may lead to the identification of targets for diagnosis and therapy in cardiovascular disease.