Changes in the structure of the mucous gel on the mucosal surface of the stomach in association with peptic ulcer disease.
Changes in the structure of the mucous gel on the mucosal surface of the stomach in association with peptic ulcer disease.
复制标题
胃粘膜表面粘膜结构的变化与消化性溃疡病相关。
DOI：
10.1016/s0016-5085(82)80241-2
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发表时间：
1982
期刊：
影响因子：
29.4
通讯作者：
C. Venables
中科院分区：
文献类型：
--
作者：
F. Younan;J. Pearson;A. Allen;C. Venables
从切除粘膜表面的粘液凝胶中分离纯化了人胃粘液的糖蛋白。所有的粘液样本经凝胶过滤分析后，都发现含有天然的、凝胶形成的聚合性糖蛋白，以及不同数量的低分子糖蛋白。低相对分子质量糖蛋白的氨基半乳糖和氨基葡萄糖含量与天然多聚糖蛋白相同。糖蛋白制剂中不含血清糖蛋白和蛋白多糖。正常胃粘膜、十二指肠溃疡患者和胃溃疡患者胃粘液中低分子糖蛋白的含量分别为33.4±5.1%、50.2±3.3%和65.1±2.B%。这些结果表明胃溃疡组的总粘液凝胶(在较小程度上，十二指肠溃疡组)含有更多的低分子粘液糖蛋白，从先前的体外研究表明，这可能是一种较弱的粘液凝胶结构。
The glycoprotein of hunian gastric mucus has been isolated and purified from mucous gel scraped from the surface of resected mucosa. All samples of mucus when analyzed by gel filtration were found to contain native, gel-forming, polymeric glycoprotein, together with varying amounts of the lower-molecular-weight glycoprotein. The galactosamine and glucosamine content of the lower-molecular-weight glycoprotein was the same as that for the native polymeric glycoprotein. The absence of seruin glycoproteins and proteoglycans in the glycoprotein preparations was demonstrated. Gastric mucus from normal mucosa obtained by resection of the antruni during pancreatoduodenectomy, from duodenal ulcer patients, and from gastric ulcer patients contained 33.4 ± 5.1%, 50.2 ± 3.3%, and 65.1 ± 2.B%, respectively, of the lower-molecular-weight glycoprotein. These results show the total mucous gel of the gastric ulcer group (and to a lesser extent, of the duodenal ulcer group) contains more lower-molecular-weight mucous glycoprotein, which from previous studies in vitro would suggest a weaker mucous gel structure.