Model-based quantitation of 3-D magnetic resonance angiographic images
Model-based quantitation of 3-D magnetic resonance angiographic images
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DOI：
10.1109/42.811279
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发表时间：
1999-10-01
影响因子：
10.6
通讯作者：
Viergever, MA
中科院分区：
文献类型：
--
作者：
Frangi, AF;Niessen, WJ;Viergever, MA
狭窄程度或血管尺寸的量化对于血管疾病的诊断和计划血管介入是重要的。尽管来自三维（3-D）磁共振血管造影（MRA）的诊断主要在二维（2-D）最大强度投影上执行，直接从3-D数据集自动量化血管段是期望的，以提供3-D数据集的准确和客观的测量。提出了一种基于模型的定量三维MRA方法。线性血管节段用耦合到血管壁表面的中心血管轴曲线建模。引入了一种新的图像特征来引导中心血管轴的变形。随后，将可变形模型的概念与采集技术的物理知识相结合，以准确地分割血管壁并计算血管直径和其他几何特性。该方法在颈动脉分叉模型上进行了说明和验证，并与地面实况和医学专家进行了比较。此外，还显示了颈动脉的3-D飞行时间（TOF）MRA图像的结果，该方法是一种很有前途的技术，直接在源3-D图像上评估几个几何血管参数，为狭窄分级提供客观机制。
Quantification of the degree of stenosis or vessel dimensions are important for diagnosis of vascular diseases and planning vascular interventions, Although diagnosis from three-dimensional (3-D) magnetic resonance angiograms (MRA's) is mainly performed on two-dimensional (2-D) maximum intensity projections, automated quantification of vascular segments directly from the 3-D dataset is desirable to provide accurate and objective measurements of the 3-D anatomy.A model-based method for quantitative 3-D MRA is proposed. Linear vessel segments are modeled with a central vessel axis curve coupled to a vessel wall surface. A novel image feature to guide the deformation of the central vessel axis is introduced. Subsequently, concepts of deformable models are combined with knowledge of the physics of the acquisition technique to accurately segment the vessel wall and compute the vessel diameter and other geometrical properties.The method is illustrated and validated on a carotid bifurcation phantom, with ground truth and medical experts as comparisons, Also, results on 3-D time-of-flight (TOF) MRA images of the carotids are shown, The approach is a promising technique to assess several geometrical vascular parameters directly on the source 3-D images, providing an objective mechanism for stenosis grading.