The other allele: exploring the long allele of the serotonin transporter gene as a potential risk factor for psychopathy: a review of the parallels in findings.
The other allele: exploring the long allele of the serotonin transporter gene as a potential risk factor for psychopathy: a review of the parallels in findings.
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DOI：
10.1016/j.neubiorev.2010.07.005
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发表时间：
2011-01
影响因子：
8.2
通讯作者：
Glenn AL
中科院分区：
文献类型：
--
作者：
Glenn AL
综合证据表明，血清素转运蛋白基因多态性的短等位基因会增加多种心理疾病的风险，包括抑郁、焦虑和酗酒。因此，短等位基因通常被认为是“风险”等位基因，而与长等位基因相关的发现很少被讨论。然而，经过更仔细的检查，与血清素转运蛋白基因的长等位基因相关的发现与精神病研究的发现有着惊人的相似之处。在此，回顾了神经心理学、心理生理学、激素和脑成像领域中与长/长基因型相关的发现与与精神变态特征相关的发现之间的相似之处。有人认为，长/长基因型可能是精神病特征发展的潜在危险因素。
Converging evidence suggests that the short allele of the serotonin transporter gene polymorphism increases risk for a variety of psychological disorders, including depression, anxiety, and alcoholism. Thus, the short allele is typically considered the “risk” allele, and findings related to the long allele are rarely discussed. However, upon closer examination, findings associated with the long allele of the serotonin transporter gene share striking similarities with findings from studies of psychopathy. Here, the parallels between findings associated with the long/long genotype and findings associated with psychopathic traits in the areas of neuropsychology, psychophysiology, hormones, and brain imaging are reviewed. It is suggested that the long/long genotype may be a potential risk factor for the development of psychopathic traits.