Quantitative evaluation of bone-resorptive lesion volume in osteonecrosis of the femoral head using micro-computed tomography
Quantitative evaluation of bone-resorptive lesion volume in osteonecrosis of the femoral head using micro-computed tomography
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DOI：
10.1016/j.jbspin.2019.09.004
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发表时间：
2020-01-01
期刊：
影响因子：
4.2
通讯作者：
Nakashima, Yasuharu
中科院分区：
文献类型：
--
作者：
Baba, Shoji;Motomura, Goro;Nakashima, Yasuharu
目的应用显微CT定量测量股骨头塌陷后骨坏死（post-collapsosteonecrosisofthemoralhead，ONFH）的骨吸收病变体积，并评价其特征。方法我们研究了35例ONFH患者（男20例，女15例;平均年龄47.2岁）的35个股骨头。在7个股骨头冠状面高分辨率micro-CT切片上，使用骨显微结构测量软件提取骨吸收区域。接下来，计算总骨吸收体积比，定义为所有七个切片中所有骨吸收横截面积与所有股骨头横截面积的比值。分析了总骨吸收体积比与性别、年龄、ONFH相关因素、患者工作负荷水平、ONFH分期、ONFH类型、磁共振成像显示的坏死体积以及疼痛发作至手术时间之间的关系。结果平均总骨吸收体积比为7.0 +/-6.0%，不同ONFH分期差异显著（阿科塌陷定量3A，3.5 +/- 2.1%; 3B，6.8 +/- 3.0%;和3C，13.6 +/- 8.8%）。ONFH分期与总骨吸收体积比独立相关（P < 0.05）。此外，高的骨吸收体积比被发现在前股骨头，并与collaps.Conclusions本研究表明，骨吸收量在后塌陷ONFH是显着相关的疾病阶段，这是更广泛的股骨头的前部比后部。(C)2019法国风湿病学会。由Elsevier Masson SAS出版。All rights reserved.
Objectives To quantify the volume of bone-resorptive lesions in post-collapse osteonecrosis of the femoral head (ONFH) using micro-computed tomography (micro-CT) and assess their characteristics in post-collapse ONFH.Methods We investigated 35 femoral heads resected from 35 patients with ONFH (20 men and 15 women; mean age, 47.2 years). On each of seven coronal high-resolution micro-CT slices of the femoral head, the bone-resorptive areas were extracted using bone microstructure measurement software. Next, the total bone-resorptive volume ratio, defined as the ratio of all bone-resorptive cross-sectional areas to all femoral head cross-sectional areas in all seven slices, was calculated. Associations between total bone-resorptive volume ratio and sex, age, ONFH-associated factors, patient workload levels, ONFH stage, ONFH type, necrotic volume on magnetic resonance imaging, and duration from the onset of pain to surgery were analyzed. Lesion location and the association between bone-resorptive lesion and collapse were also evaluated.Results The mean total bone-resorptive volume ratio was 7.0 +/- 6.0%, which varied significantly by ONFH stage (ARCO collapse quantitation 3A, 3.5 +/- 2.1%; 3B, 6.8 +/- 3.0%; and 3 C, 13.6 +/- 8.8%). ONFH stage was independently associated with total bone-resorptive volume ratio (P < 0.05). Furthermore, high boneresorptive volume ratios were found in the anterior femoral head and were associated with collapse.Conclusions This study demonstrated that bone-resorptive volume in post-collapse ONFH was significantly associated with the disease stage, which was more widespread in the anterior portion of the femoral head than in the posterior portion. (C) 2019 Societe francaise de rhumatologie. Published by Elsevier Masson SAS. All rights reserved.