Data of cytotoxicity, p53 and Akt downstream proteins and physiological indexes in hepatocellular carcinoma cells or HepG2-bearing nude mouse model administered by α-Humulene

Data of cytotoxicity, p53 and Akt downstream proteins and physiological indexes in hepatocellular carcinoma cells or HepG2-bearing nude mouse model administered by α-Humulene
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α-Humulene对肝癌细胞或HepG2裸鼠模型的细胞毒性、p53和Akt下游蛋白及生理指标数据

DOI:
10.1016/j.dib.2020.105325
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发表时间:
2020-02
期刊:
影响因子:
1.2
通讯作者:
Xinzhou Yang
Xinzhou Yang
中科院分区:
--
文献类型:
--
作者:
Hao Chen;Ji Hao;Yanzhang Wen;Yibing Lv;Lu Chen;Jingquan Yuan;Xinzhou Yang

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该数据文章包含与题为“α-蛇麻烯通过抑制Akt信号传导抑制肝细胞癌(HCC)细胞增殖并诱导细胞凋亡”的研究文章相关的数据(Chen et al.,2019年)[1]。本文就α-蛇麻烯(α-Humulene,HML)的抗肝癌细胞增殖作用及其机制进行综述。在这些数据中,HML在几种HCC细胞系中的细胞毒性被报道,以及涉及p53和Akt下游的蛋白质的变化。还提供了荷HepG 2裸鼠模型的体重曲线、血液生化参数和器官指数,提示HML给药的潜在副作用。
This data article contains data related to the research article entitled “α-Humulene inhibits hepatocellular carcinoma (HCC) cell proliferation and induces apoptosis through the inhibition of Akt signaling” (Chen et al., 2019) [1]. The article focuses on the antiproliferation of α-Humulene (HML) and the mechanisms involved in HCC cells inhibition. In this data, cytotoxicity of HML in several HCC cell lines are reported, together with the changes in proteins involving in p53 and Akt downstream. Weight curve, blood biochemical parameters and organ indices from HepG2-bearing nude mouse model are also provided, suggesting the potential side effects in HML administration.
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影响因子: 5.7
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