Dynamically Crosslinked Gold Nanoparticle - Hyaluronan Hydrogels
Dynamically Crosslinked Gold Nanoparticle - Hyaluronan Hydrogels
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DOI：
10.1002/adma.201001436
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发表时间：
2010-11-09
影响因子：
29.4
通讯作者：
Prestwich, Glenn D.
中科院分区：
文献类型：
--
作者：
Skardal, Aleksander;Zhang, Jianxing;Prestwich, Glenn D.
生物打印包括自动沉积细胞和生物材料，以模拟组织的结构。金纳米粒子作为硫醇修饰的透明质酸和明胶的动态多价交联剂。合成的细胞外基质可以生物打印成支持细胞增殖和基质重塑的管状结构。该图显示了x-y平面中的组织结构(包含荧光染料)的视图，插图显示了所使用的打印头。
Bioprinting consists of automated deposition of cells and biomaterials to mimic the architecture of a tissue. Gold nanoparticles act as dynamic, multivalent crosslinkers for thiol-modified hyaluronic acid and gelatin. The resulting synthetic extracellular matrix can be bioprinted into tubular constructs that support cell proliferation and matrix remodeling. The figure shows a view of a tissue construct (containing a fluorescent dye) in the x-y plane, and the inset shows the print head used.